The Role of Lactate in Viral and Bacterial Infection

Completed

• Conditions: Bacterial Infections; Lactate Blood Increase; Viral Infection
• Interventions: Other: viral infection; Other: viral and bacterial infection

• Registration Number: NCT04777747
• Lead Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Brief Summary

Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.

Detailed Description

Lactate is an important molecule in the spread and metastasis of tumor by suppressing the innate immune response. As is known, the immune system is not mature in children and it is reverse related to the age of children. An reasonable hypothesis is that the lactate is a independent risk factor in the children with viral infection progress to bacterial infection. Here, our aim is to test the hypothesis.

Study Timeline

• Study Start: 2021-01-01
• Study First Submitted: 2021-02-26
• Study First Submitted QC: 2021-03-01
• Study First Posted: 2021-03-02
• Status Verified: 2022-10
• Primary Completion: 2023-03-31
• Study Completion: 2023-03-31
• Last Update Submitted: 2023-04-28
• Last Update Posted: 2023-05-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• child's age is from 0 to 18 years
• a child is at least diagnosed with viral infection

Exclusion Criteria

one of the following conditions appeared:

• congenital heart disease or other abnormalities
• respiratory failure
• hereditary and/or metabolic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
viral infection	viral infection	a child is infected by virus only
viral and bacterial infection	viral and bacterial infection	a child is infected by virus and progress to bacterial infection

Primary Outcome Measures

Name	Time	Method
the level of lactate dehydrogenase(LDH)	three days after admission	level of LDH in both viral and viral and bacterial infection groups
level of lactate	three days after admission	level of lactate in both viral and viral and bacterial infection groups

Trial Locations

Locations (1)

Chen; 🇨🇳 Chongqing, Chongqing, China