Towards cost-effective diagnostic management of patients with primary aldosteronism: adrenal vein sampling or CT-scan?

Completed

• Conditions: conn's disease; primary aldosteronism; 10001353; 10057166

• Registration Number: NL-OMON34699
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

Patients ><=18 years of age
-with hypertension, resistant to two adequately dosed antihypertensive drugs with or without
hypokalemia, either spontaneous or diuretic-induced.
-willing and fit to undergo surgery for adrenal adenoma

Exclusion Criteria

pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The criterion ('gold') standard of correct strategy will be medication use<br /><br>after one year of follow-up. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoints will be costs of each strategy, quality of life, serum<br /><br>potassium, proportion of patients with normal blood pressure with or without<br /><br>medication, and normalization of aldosterone (after Adx only). Costs of each<br /><br>strategy consist of immediate costs and long-term extrapolated costs of<br /><br>diagnosis and surgical and medical treatment in both arms.</p><br>