ACTRN12610000524099已完成不适用
The role of wheat gluten in the genesis of gastrointestinal symptoms and fatigue in patients with non-coeliac gluten intolerance: Investigation of the gluten ‘intolerance’ threshold level.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Diagnosis
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 16 Years 至 o limit（—）
- 性别
- All
入选标准
- •1. Met Rome III criteria for Irritable Bowel Syndrome (IBS) prior to implementation of gluten-free diet (GFD)
- •2. Current gastrointestinal (GI) symptoms well-controlled on a GFD
- •3. Adherent to a strict GFD for the previous 6 weeks.
- •4. Coeliac disease excluded by either normal duodenal histology while consuming a gluten-containing diet or by having a genotype that is inconsistent with coeliac disease (Human Leukocyte Antigen (HLA) -DQ2 and -DQ8 negative)
排除标准
- •1. Other significant GI disease (e.g., cirrhosis, inflammatory bowel disease) or other clinically significant co-morbidity.
- •2. Intake of non-steroidal anti-inflammatory drugs
- •3. Use of systemic immunosuppressant medication (e.g., prednisolone, methotrexate, thiopurines, anti-tumour necrosis factor drugs)
- •4. Excessive alcohol intake
- •5. Poorly controlled psychiatric disease
- •6. Unable to give written/informed consent
研究者
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