B-cell memory and humoral immune response after primary immunization against tick borne encephalitis (TBE) in the elderly - Vaccine-induced immunity against TBE in the elderly
- Conditions
- This study will investigate immunity against tick-borne encephalitis (TBE) following primary TBE vaccination in healthy volunteers 18-30 years or > 60 years who fulfill the local criteria for TBE vaccination (tick exposure possible).MedDRA version: 9.1Level: LLTClassification code 10036897Term: Prophylactic vaccination
- Registration Number
- EUCTR2007-005645-38-AT
- Lead Sponsor
- Clinical Institute of Virology, Medical University of Vienna
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Age < 30 years or > 60 years
Criteria or TBE-vaccination fulfilled (tick exposure possible)
Healthy according to the questionaire (completed before screening)
Capable to understand and sign informed consent form (based on the judgment of the study physician)
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Previous vaccination against TBE or diseases caused by other flaviviruses (Japan B encephalitis, yellow fever)
Contraindication for TBE vaccination (according to SmPC 2007)
Immunodeficiency, history of autoimmune disease or current intake of immunemodulating drugs (corticosteroids)
Past medical history and/or current treatment for chronic cardiac, pulmonary or kidney disease, previous stroke, epilepsy, Parkinson’s disease, dementia, marcoumar therapy
Pregnancy or lactation
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method