The relevance of donorspecific memory B cells in immunised kidney transplant recipients

Completed

• Conditions: orgaantransplantatie; End-stage renal failure; kidney transplantation; 10029149

• Registration Number: NL-OMON39729
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

Kidney transplant recipients who receive a kidney transplant after having rejected their previous transplant. Additionally, thier kidney donors in case of living donor transplantation.

Exclusion Criteria

Subjects infected with HIV or Hepatitis C

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameter to be assessed in the current study is the frequency of<br /><br>donor-specific memory B cells as determined by a novel ELISPOT based technique.<br /><br>Furthermore, donor-specific antibody levels will be determined by CDC and<br /><br>Luminex techniques.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters are clinical parameters. The transplant function<br /><br>at 6 and 12 months will be determined by using the estimated Glomerular<br /><br>Filtration Rate (eGFR). Furthermore, the occurence of cellular and antibody<br /><br>mediated rejection within the first year after transplantation will be<br /><br>recorded,</p><br>