Effect of Exercise Training in Lung Cancer

Not Applicable

Completed

• Conditions: Lung Cancer, Nonsmall Cell
• Interventions: Other: Pulmonary Exercises; Other: Aerobic training

• Registration Number: NCT05158530
• Lead Sponsor: Riphah International University

Brief Summary

To determine the effects of exercise training in patients with lung cancer during chemotherapy treatment. In currently accessible literature, majority studies, met-analysis, and systemic reviews are related to surgical procedures and post-op pulmonary Rehabilitation of patients with Lung cancer. In literature, Gap related to the control group was observed also. The current study aimed to fulfill this gap by planning a structured intervention plan for the control group as well. It will also add in literature the deficiency of oncology rehab for patients receiving chemotherapy only.

Detailed Description

Literature suggested that a pulmonary rehabilitation program for patients with non-small cell lung cancer undergoing induction chemo-radiotherapy seems to improve respiratory function. It is particularly recommended for smokers and patients with respiratory impairment.

Study Timeline

• Study First Submitted: 2021-12-13
• Study First Submitted QC: 2021-12-13
• Study First Posted: 2021-12-15
• Study Start: 2021-12-20
• Status Verified: 2022-04
• Primary Completion: 2022-04-01
• Study Completion: 2022-04-01
• Last Update Submitted: 2022-04-04
• Last Update Posted: 2022-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Diagnosed patients of stage 1 and 2 Non-small cell lung carcinoma (NSCLC) including Adenocarcinoma & squamous cell carcinoma The diagnosis was established within 6 wk prior to enrollment and was confirmed by histology.

Participants are undergoing lung cancer chemotherapy Participant has the willingness to participate in training WHO physical fitness scores 0-1 Able to perform 6-minute walk test (6MWT) at baseline

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Exclusion Criteria

• • Participant with history of trauma and surgery

  • Patients with lung disease other than lung cancer
  • Uncontrolled hypertension or unstable coronary artery disease.
  • Severe OA, bone or CNS metastases.
  • hemoglobin <10 g/dL
  • Lower than 3,500 white blood cells per microliter of blood

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Pulmonary Exercises	Pulmonary exercises, 3 sessions per week and 3-5 repetitions in a session for 4 weeks.
Interventional Group	Aerobic training	Pulmonary exercises + Aerobic training, 40%-60% intensity 3 days/ week for 4 weeks

Primary Outcome Measures

Name	Time	Method
6 min walk test: Distance (meters)	4 weeks	Changes from the baseline, 6 min walk test (6 MWT) was used to measure Functional capacity. It is a sub maximal exercise test which can aid in assessing functional capacity of patients with cardiopulmonary diseases, in this test we find out the maximum distance in meters which an individual covers in 6 min without any support.
Forced Expiratory Volume in 1 second (FEV1)	4 weeks	Changes from the Baseline, the digital spirometer is used in clinical setting to analyze Forced Expiratory Volume in 1 second FEV1 in Liters
Forced vital Capacity (FVC)	4 weeks	Changes From the Baseline, the digital spirometer is used in clinical setting to analyze Forced vital Capacity in Liters
Rate of perceived exertion (RPE)	4 weeks	Changes From the Baseline, measured through Borg RPE scale which measures a person's perception of their effort and exertion breathlessness, and fatigue during physical work rating between 1 and 10. The higher the number, the more intense the exercise. An RPE of 1 is often referred to as just above rest, hardly any exertion, while an RPE of 10 is a maximal effort.

Secondary Outcome Measures

Name	Time	Method
Hospital Anxiety and Depression	4 weeks	The Hospital Anxiety and Depression Scale (HADS) is a frequently used self-rating scale developed to assess psychological distress in non-psychiatric patients. HADS is a fourteen-item scale with seven items each for anxiety and depression subscales. Scoring for each item ranges from zero to three. A subscale score \>8 denotes anxiety or depression
Mindfulness	4 weeks	Changes From the Baseline, measured through MAAS. The MAAS is a 15-item scale designed to assess a core characteristic of dispositional mindfulness, namely, open or receptive awareness of and attention to what is taking place in the present. The scale shows strong psychometric properties and has been validated with college, community, and cancer patient samples.Higher scores reflect higher levels of dispositional mindfulness

Trial Locations

Locations (1)

Institute of Radiotherapy and Nuclear Medicine; 🇵🇰 Peshawar, KPK, Pakistan