Two different treatments methods with Platelet fibrin and Laser to see which one speeds up the process of moving canine teeth in orthodontic patients.
- Conditions
- Other specified disorders of teethand supporting structures,
- Registration Number
- CTRI/2024/05/067851
- Lead Sponsor
- Dr Puja Priya
- Brief Summary
Treatment duration is one of the prime concerns for patients before starting orthodontic treatment. Various treatment approaches have been tried for acceleration of orthodontic treatment. This study will be comparing between pharmacological method using PRF and physical method using LLLT therapy. Platelet rich fibrin (PRF) has been defined as the 2nd generation platelet rich protein (PRP) where autologous platelets and leukocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue, and accelerate tooth movement. Low Level Laser Therapy (LLLT) also known as Photo-biomodulation is a low powered laser (10mW–1W) with a wavelength of (650 -980nm). Both PRF clot and LLLT can speed up the rate of orthodontic tooth movement. However, the overall quality of evidence ranged from low to very low and the clinical significance of the obtained statistically significant differences is questionable. Hence more precise studies are needed to know which one is faster and more effective among the two so that clinicians can routinely use it in clinical practice as both process will have good patient acceptance. One of the most important cytokines that appears at initial stage of orthodontic tooth movement is IL-1beta. This study will also compare the levels of IL-1beta in both the experimental sites for better understanding at cellular level.
Null hypothesis (H0): There is no difference in the tooth movement between the PRF method and LLLT method.
Alternate hypothesis (H1): There is a difference in the tooth movement between the PRF and LLLT method.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 10
- Presence of permanent dentition with mild crowding.
- Patients having Class I molar relationship bilaterally.
- Indication of extraction of 1st premolars bilaterally in the treatment plan.
- Good oral hygiene.
- Previous orthodontic treatment Underlying periodontal disease or TMJ disorder Syndromic patient.
- Mixed dentition patients Missing or impacted tooth.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tooth movement increase, T0 On the day of extraction | T1 7days after extraction | T2 14 days after extraction | T3 28 days after extraction | T4 42 days after extraction | T5 56 days after extraction
- Secondary Outcome Measures
Name Time Method IL-1 beta appearance in Platelet rich fibrin and Low level laser site T0 On the day of extraction
Trial Locations
- Locations (1)
Bharati Vidyapeeth Dental Hospital, Navi Mumbai
🇮🇳Raigarh, MAHARASHTRA, India
Bharati Vidyapeeth Dental Hospital, Navi Mumbai🇮🇳Raigarh, MAHARASHTRA, IndiaDr Harsh MishraPrincipal investigator02227564654drmishraharsh@gmail.com