Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease

Completed

• Conditions: Chronic Kidney Disease
• Interventions: Device: Diffuse Optical Spectroscopy

• Registration Number: NCT00793806
• Lead Sponsor: University of California, Irvine

Brief Summary

The common causes of mortality are late stages of chronic kidney disease, cardiovascular disease and infections, are associated with abnormalities of the immune system, an underlying state of chronic inflammation and oxidative stress. These processes have not been carefully described in the chronic kidney disease population. The researcher can use Diffuse Optical Spectroscopy to determine the immune system in individuals with chronic kidney disease and describe the association with chronic inflammation and oxidative stress in that population.

Detailed Description

The Diffuse Optical Spectroscopy can measure the absolute concentrations of reduced and oxygenated hemoglobins,cardiac output, mean arterial pressure, blood loss,blood hemoglobin concentration, water and lipid concentrations of the tissue.

The researchers can use Diffuse Optical Spectroscopy to monitor volume changes during the hemodialysis treatment and to correlate the changes in volume and blood pressure with the measures of oxidative stress and inflammation used in this study. The researchers can use Diffuse Optical Spectroscopy data to compare to laboratory parameters routinely measured to clinical parameters such as cause of chronic kidney disease, blood pressure and dialysis-related parameters.

Study Timeline

• Study Start: 2008-08
• Study First Submitted: 2008-11-14
• Study First Submitted QC: 2008-11-18
• Study First Posted: 2008-11-19
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-19
• Last Update Posted: 2022-10-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• 18 years and older with chronic kidney disease undergoing hemodialysis have been treated with hemodialysis for at least 3 months
• 18 years and older for control

Exclusion Criteria

• acute kidney disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Medical Tool	Diffuse Optical Spectroscopy	Diffuse Optical Spectroscopy measurements will be compared to a variety of laboratory parameters routinely measured in Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease

Primary Outcome Measures

Name	Time	Method
Medical Tool	4 weeks	Diffuse Optical Spectroscopy measure blood values changes during the hemodialysis treatment.

Trial Locations

Locations (3)

University of California Medical Center: Dialysis Unit; 🇺🇸 Orange, California, United States

UCIMC Dialysis center; 🇺🇸 Orange, California, United States

Beckman Laser Institute; 🇺🇸 Irvine, California, United States