Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 3
- 主要终点
- Medical Tool
研究概览
简要总结
The common causes of mortality are late stages of chronic kidney disease, cardiovascular disease and infections, are associated with abnormalities of the immune system, an underlying state of chronic inflammation and oxidative stress. These processes have not been carefully described in the chronic kidney disease population. The researcher can use Diffuse Optical Spectroscopy to determine the immune system in individuals with chronic kidney disease and describe the association with chronic inflammation and oxidative stress in that population.
详细描述
The Diffuse Optical Spectroscopy can measure the absolute concentrations of reduced and oxygenated hemoglobins,cardiac output, mean arterial pressure, blood loss,blood hemoglobin concentration, water and lipid concentrations of the tissue.
The researchers can use Diffuse Optical Spectroscopy to monitor volume changes during the hemodialysis treatment and to correlate the changes in volume and blood pressure with the measures of oxidative stress and inflammation used in this study. The researchers can use Diffuse Optical Spectroscopy data to compare to laboratory parameters routinely measured to clinical parameters such as cause of chronic kidney disease, blood pressure and dialysis-related parameters.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years and older with chronic kidney disease undergoing hemodialysis have been treated with hemodialysis for at least 3 months
- •18 years and older for control
排除标准
- •acute kidney disease
结局指标
主要结局
Medical Tool
时间窗: 4 weeks
Diffuse Optical Spectroscopy measure blood values changes during the hemodialysis treatment.
次要结局
未报告次要终点
研究者
Beckman Laser Institute and Medical Center
Madeleine Pahl, M.D., Associate Professor of Medicine and Director of the Renal Clinic
University of California, Irvine