To study the effect of repetitive transcranial magnetic stimulation and amitryptilline on migraine headache

Not yet recruiting

Brief Summary: This study is a randomized parallel group study comparing the efficacy of repetitive transcranial magnetic stimulation(rtms) on migraine/chronic daily headache patients given either alone or in combination with amitryptilline. One group of patients will receive high frequency rtms on daily basis for 3 days for 3 consecutive months.The second group will be given rtms on similar protocol and will also be additionaly given upto 50 mg of amitryptilline. Patient will also be subjected to hearing threshold, brainstem evoked potential and visual evoked potential during the course of treatment. The primary outcome shall be to reduction of frequency and severity of headache in the two group of patients at 1 2 and 3 months. the secondary outcome shall be the effect of treatment on hearing threshold, brainstem evoked potential and visual evoked potential.

Recruitment & Eligibility

Inclusion Criteria

primary headache-migraine and chronic daily headache.

Exclusion Criteria

All patients having any neurological morbidity due to any hereditary, trauma, seizure disorder, meningitis, arterio-veinous malformation, stroke, infection, dyselectrolytemia and any possible secondary cause of headache shall be excluded.
Pregnancy, liver or kidney failure, malignancy, uncontrolled diabetis and hypertension or headache with underlying psychiatric illness shall be excluded.

Primary Outcome Measures

Name	Time	Method
The primary out come will be defined as 50% decreases in severity and frequency of headache, at each follow-up visit	1 2 and 3 months

Secondary Outcome Measures

Name	Time	Method
Effects on habituation viz hearing threshold and brainstem evoked potentials and visual evoked potentials,	1 2 and 3 months

Locations (1): SGPGIMS Lucknow
🇮🇳
Lucknow, UTTAR PRADESH, India
SGPGIMS Lucknow
🇮🇳Lucknow, UTTAR PRADESH, India
Dr Jayantee Kalita
Principal investigator
8004904630
jayanteek@yahoo.com