A study to compare decrease in stress response during skull pin insertion between intravenous dexmedetomidine and local infiltration of ropivacaine.
Not Applicable
Completed
- Conditions
- Health Condition 1: G938- Other specified disorders of brainHealth Condition 2: null- Patients of 18-65 years ASA grade 1 to 3 scheduled to undergo elective craniotomy under general anaesthesia requiring application of head- holder.
- Registration Number
- CTRI/2019/02/017784
- Lead Sponsor
- Department of anaesthesiology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 88
Inclusion Criteria
ASA grade 1 to 3 undergoing elective craniotomy under general anaesthesia requiring application of head holder.
Exclusion Criteria
bradycardia( <50)
second or third degree heart block
uncontrolled hypertention
cardiac, renal or hepatic disease
history of beta blocker intake
glasgow coma scale <13
pitutary disease
known allergic to local anaesthetic or dexmedetomidine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of efficacy of intravenous dexmedetomidine in decreasing skull pin insertion response i.e. alteration in heart rate, mean arterial pressure, BIS, perfusion index,serum cortisol, serum prolactin& blood glucose.Timepoint: Vitals are recorded at baseline, after induction, after intubation, 1, 3, 5 minutes after intubation, before and after study drug , before and after skullpin insertion, 1, 3, 5, 10, 15, 20 minutes after skullpin insertion . serum cortisol ,prolactin and blood sugar are measured baseline and 30 minutes after skullpin insertion.
- Secondary Outcome Measures
Name Time Method systolic blood pressure, diastolic blood pressure, end tidal carbon dioxide level, SpO2, Fiso will be notedTimepoint: Recorded at baseline, after induction, after intubation, 1, 3, 5 minutes after intubation, before and after study drug , before and after skullpin insertion, 1, 3, 5, 10, 15, 20 minutes after skullpin insertion