Vitamin D treatment effect on retinal nerve fiber loss after optic neuritis.
- Conditions
- Multiple sclerosis, MS, vitamin D, optic neuritis, optical coherence tomography, OCT.Vitamine D, neuritis optica.
- Registration Number
- NL-OMON26942
- Lead Sponsor
- Erasmus Medical Center, Rotterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
1. Single unilateral ON;
2. Age between 18 and 50 year;
Exclusion Criteria
1. Prior known ON, MS or prior symptoms suggestive of demyelination;
2. Other suspected or established causes of vision loss (e.g. glaucoma, amblyopia);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Retinal nerve fiber layer thickness, as measured by OCT at 6 months, 1 year and 2 years.
- Secondary Outcome Measures
Name Time Method 1. Time to second attack;<br /><br>2. Visual acuity and visual field at 6 months, 1 year and 2 years;<br /><br>3. Clinical outcome measures (EDSS, MSIS, FSS, HADS) at 6 months, 1 year and 2 years;<br /><br>4. T2 lesion load on brain MRI at 2 years;<br /><br>5. Markers of immunology and neurodegeneration and T cell function at 6 months, 1 year and 2 years.