PET/MRI Study on Changes of Fat and Muscle Metabolism.
- Conditions
- Differential DiagnosisBrown Fat and Muscle Metabolic
- Interventions
- Other: Comprehensive treatment of tumor
- Registration Number
- NCT04334720
- Lead Sponsor
- Tang-Du Hospital
- Brief Summary
False positives for Brown Fat \& Muscle（F\&M） always affect the evaluation of metabolic disease treatment. Recently, using PET/CT，international journals such as Journal of Nuclear Medicine reported that the amount of active brown fat was correlated with renal creatinine clearance and subject to regulation by atrial natriuretic peptide in addition to association of season and temperature. At present，studies based on PET/CT have shown that elimination of the above factors, brown fat(even muscle) will still appear false positive metabolism in tumor patients. In view of the basis of Positron emission computed tomography/Magnetic resonance (PET/MRI) brain function research，our team speculate that it may be related to psychological or cortex metabolism. And there is a lack of studies on the correlation between the psychosocial，cortex structure and metabolism. Therefore, it suggests that，combination of structure and metabolism，PET/MRI will play a role in studying the effects of psychological on F\&M false-positive metabolism in malignant patients. In this project, the investigators intend to observe the changes of F\&M metabolism with psychological and cortex metabolism after comprehensive treatment in malignant patient by combining PET/MRI. The relationship between F\&M metabolism and psychological will be deeply analyzed to provide scientific basis for the development of the differential diagnosis and assessment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
- Clinical diagnosis of malignant tumor
- Have not yet been receiving comprehensive treatment and should begin within one month
- Fasting glucose of diabetic patients is controlled below 11.1 mmol/L.
Inclusion Criteria for Healthy Control Participants:
• Clinical diagnosis of Healthy Control
- Fasting glucose ≥11.1mmol/L
- History of endocrine disease (such as chronic glomerulonephritis, Addison's disease)
- Neurological signs and/or history of neurological disease
- Have begun comprehensive treatment
- Presence of magnetically active objects in the body
- Claustrophobia or any other medical condition that would preclude the participant from lying in the PET/MRI scanner for approximately 40 mins.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Observation group of positive F&M Comprehensive treatment of tumor The baseline PET/MR scan was performed before comprehensive treatment, and the contrast scan was performed after treatment and the sequence and protocol was consistent. Get psychological assessment before and after treatment and the time interval shall not exceed half a year Observation group of no abnormal changes in F&M Comprehensive treatment of tumor The baseline PET/MR scan was performed before comprehensive treatment, and the contrast scan was performed after treatment and the sequence and protocol was consistent. Get psychological assessment before and after treatment and the time interval shall not exceed half a year
- Primary Outcome Measures
Name Time Method Change of activated M&F volume Baseline, 1 day ( Contrast scanning) Activated M\&F volume before and after comprehensive treatment were evaluated by post-processing software
Change of M&F SUVmax and SUVmean Baseline, 1 day ( Contrast scanning) SUVmax and SUVmean scores will be measured by post-processing software.
Change of anxiety symptoms Baseline, 1 day ( Contrast scanning) Anxiety symptoms scores will be assessed with Hamilton Anxiety Scale.
Change metabolism of glucose of M&F Baseline, 1 day ( Contrast scanning) Glucose metabolic scores will be assessed with visual scale
Change of metabolism of glucose in the M&F Baseline, 1 day ( Contrast scanning) Accumulation of 18F-FDG will be analyzed by treatment-related, psychology-related and intervention-related Positron emission tomography/ Magnetic resonance
Change of the glucose metabolism area of M&F Baseline, 1 day ( Contrast scanning) Five different anatomical locations (subphrenic, paravertebral, mediastinal, cervical, supraclavicular) will be assessed with visual.
Change of sleep Baseline, 1 day ( Contrast scanning) Sleep scores will be assessed with Pittsburgh sleep quality index one month before scanning
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tangdu Hospital
🇨🇳Xi'an, Shaanxi, China