Resistance Exercise Training at Different Intensities

Not Applicable

Completed

• Conditions: Frailty; Sarcopenia; Aging
• Interventions: Behavioral: Low Load Resistance exercise; Behavioral: High Load Resistance exercise

• Registration Number: NCT04053920
• Lead Sponsor: University of Glasgow

Brief Summary

The aim of the current study, therefore, is to determine the feasibility of recruitment and adherence to resistance exercise training interventions performed at low and high loads, to volitional muscular failure, in a trial population that includes both healthy and frail older people.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-01
• Study First Submitted: 2019-08-09
• Study First Submitted QC: 2019-08-09
• Study First Posted: 2019-08-13
• Primary Completion: 2019-12-18
• Study Completion: 2019-12-18
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-24
• Last Update Posted: 2020-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Over age of 65 years

Exclusion Criteria

• Current participation in an exercise programme
• Exercise deemed unsafe by clinical team

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Low load	Low Load Resistance exercise	Training at 30-40% one-repetition maximum (1RM)
High load	High Load Resistance exercise	Training at 65-75% one-repetition maximum (1RM)

Primary Outcome Measures

Name	Time	Method
Muscle strength	Change from baseline to 8 weeks	Knee extensor maximal torque during an isometric MVC

Secondary Outcome Measures

Name	Time	Method
One-repetition maximum	Change from baseline to 8 weeks	leg extension, leg curl, leg press and calf press
Short performance physical battery test	Change from baseline to 8 weeks	SPPB - balance, walking pace and chair rise
Muscle strength	Change from baseline to 8 weeks	Knee flexor maximal torque during an isometric MVC
Vastus lateralis muscle thickness	Change from baseline to 8 weeks	Measured via ultrasound
Biomechanics during walking and stair climbing	Change from baseline to 8 weeks	Motion analysis
Quality of life measure	Change from baseline to 8 weeks	EQ-5D-5L questionnaire

Trial Locations

Locations (1)

GRI Clinical Research Facility; 🇬🇧 Glasgow, United Kingdom