Resistance Exercise Training in Chronic Kidney Disease
- Conditions
- Chronic Kidney Disease
- Interventions
- Behavioral: Resistance exercise training
- Registration Number
- NCT03120416
- Lead Sponsor
- University of Illinois at Chicago
- Brief Summary
The investigators aim to evaluate the feasibility of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function.
- Detailed Description
Resistance exercise training has been shown to improve cardiovascular health including endothelial function in general populations, but studies in patients with chronic kidney disease (CKD) are limited. The investigators aim to evaluate the feasibility and acceptability of a resistance exercise training program among individuals with CKD and its impact on endothelial and vascular function as measured by brachial artery flow-mediated dilation, pulse-wave velocity and carotid artery stiffness. To accomplish this goal the investigators propose to conduct a 12-week pilot randomized controlled trial of twice a week resistance exercise training among 32 adults with CKD. The results of this study will inform the design and implementation of a larger trial evaluating the impact of resistance exercise training on adverse outcomes in patients with CKD including CKD progression.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 34
- CKD stage 3 or 4 (eGFR 15-60 ml/min/1.73m2)
- Currently institutionalized
- Kidney transplant or dialysis
- NY Heart Association class 3-4 heart failure
- Dementia or cognitive impairment
- Unstable angina or coronary revascularization within the last 3 months
- Uncontrolled arrhythmia
- Severe chronic lung disease
- Orthopedic, neurologic or other condition that would preclude resistance exercise training
- Pregnancy
- Uncontrolled hypertension (systolic > 160 mmHg and diastolic >90 mmHg)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Resistance exercise training program Resistance exercise training Eight exercises will be used to include large upper and lower body muscle groups. The baseline 1 repetition maximum (RM) will be used to set initial training loads. All exercise sessions will be performed under the supervision of an exercise physiologist. Vital signs and body weight will be recorded before each session. The workload during training will be adjusted to reflect 80% of the most recent 1 RM (approximately 8-12 RM set). In addition, patients' workloads will be progressively increased if the patients can lift the weight more than 12 repetitions. Participants will perform three sets of 8-12 repetitions on each machine per session.
- Primary Outcome Measures
Name Time Method Endothelial function 3 months Measured by brachial artery flow-mediated dilation (FMD)
- Secondary Outcome Measures
Name Time Method Objectively measured physical activity 3 months Assessed by a physical activity monitor (ActiGraph GT3X+)
Serum LDL-cholesterol 3 months Measured using standard procedures
Vascular function 3 months Measured by pulse wave velocity
Carotid artery stiffness 3 months Measured by non-invasive ultrasound
Systolic blood pressure 3 months Measured using standard procedures
Muscle strength 3 months Assessed by the amount of weight lifted in a single chest press and leg press (1 RM).
Self-reported physical activity 3 months Assessed by the MESA (Multiethnic Study of Atherosclerosis) Typical Week Physical Activity Survey
Serum HDL-cholesterol 3 months Measured using standard procedures
Trial Locations
- Locations (1)
University of Illinois at Chicago
🇺🇸Chicago, Illinois, United States