Pretreatment Electroencephalogram (EEG) May Predict Electroconvulsive Therapy(ECT) Effect in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- EEG functional connectivity difference between response and nonresponse group
研究概览
简要总结
This study is designed to find quantitative Electroencephalogram(qEEG) biomarkers to predict Electroconvulsive Therapy(ECT) Response in Schizophrenia
详细描述
The purpose of this proposal is to explore quantitative Electroencephalogram(qEEG) biomarkers that would predict Electroconvulsive Therapy(ECT) Response in Schizophrenia (SZD). The investigators will recruit 30 SZD patients who are preparing for ECT treatment and assesse psychotic symptoms using Positive and Negative symptom scale(PANSS) before and after 8-sessions clinical course of ECT treatment. These patients needed ECT treatment are assessed by clinicians according to American Psychiatric Association(APA) guidelines. Meanwhile resting EEG will be recorded for 10 minutes before the first episode of ECT treatment. Decrease of PANSS scores will be calculated after the last session of ECT treatment to distinguish responder/non-responder.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DSM-5 criteria for SZD
- •patients needed ECT treatment assessed by clinicians using American psychological Association(APA) guidelines.
- •symptoms must be of at least moderate severity (PANSS score >71)
- •age between 18 to 60 years old
- •medications will be stable for at least four weeks prior to ECT, and there will be no dose changes unless medically necessary
排除标准
- •any additional current psychiatric comorbidity
- •pregnancy or prepare to have a baby
- •current use of any Antiepileptic drugs
- •history of taking any kinds of Physicotherapeutics within 6 months
- •severe psychotic symptoms that make patients could not accomplish the clinical interview
结局指标
主要结局
EEG functional connectivity difference between response and nonresponse group
时间窗: through study completion, an average of 6 months
This is a predictive indicator collected before ECT treatment. After treatment, we divided 30 patients into response and nonresponse group using PANSS. Then we explore differences in pretreatment EEG functional connectivity at different frequency bands (Alpha, Beta, Delta, and Theta) to find a predictable biomarker for ECT treatment effect.
Change in Positive and negative syndrome scale（PANSS）score
时间窗: up to 4 weeks
It assessed the severity of psychotic symptoms.The responder on PANSS is defined as a PANSS decrease at least 25% from the baseline at post-treatment. PANSS helps us divide cases into response and nonresponse group.
次要结局
未报告次要终点
研究者
Zhen Wang
vice-president
Shanghai Mental Health Center