Postoperative Recovery After Abdominal Hysterectomy: A Randomised Clinical Trial of Methadone Compared to Morphine

Phase 4

Withdrawn

• Conditions: Hysterectomy; Pain after total abdominal hysterectomy; Postoperative Recovery; Anaesthesiology - Pain management; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12615000615583
• Lead Sponsor: Monash Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-06-12
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

1.ASA I, II or III
2.Elective abdominal hysterectomy
3.Age < 80

Exclusion Criteria

1.Refusal to participate
2.Unable to consent
3.Non-English speaking background with inadequate spoken English to complete questionnaire
4.Planned pelvic exenteration or radical hysterectomy
5.Adverse drug reaction to morphine or methadone, or inability to receive a volatile anaesthetic
6.Chronic pain, or taking any regular opioid or chronic pain medication pre­operatively (paracetamol, NSAIDs, or tramadol is not an exclusion criteria)
7.History of intravenous drug use
8.Preoperative renal failure (with eGFR < 60 mL/min), known obstructive sleep apnoea, morbid obesity (BMI > 40 kg/m2), or severe COAD (FEV1 < 50% predicted)
9.Use of CYP 2B6 inducers or inhibitors: rifampicin, antiepileptics (carbamazepine, phenobarbital, phenytoin), sertraline, antiplatelets (clopidogrel, prasugrel, ticlopidine), antivirals (efavirenz, nevirapine)
10.Use of antipsychotic medication
11.Patients with a prolonged QT interval (> 440ms) on preoperative ECG
12.Use of selective monoamine oxidase B inhibitors: selegiline, rasagiline

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of Recovery score (QoR-40)[24 hours after surgery completion]