Effects of magnesium sulfate and pregabalin on postoperative pain in posterior lumbar spinal fusion surgery

Phase 3

Recruiting

Conditions: Fusion of spine, lumbar region.
Fusion of spine, lumbar region
M43.26

Registration Number: IRCT20190703044091N1

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

Patients between the ages of 18 and 70 years
Patients undergoing posterior lumbar spinal fusion surgery

Exclusion Criteria

Patients with hepatic dysfunction (transaminases above normal levels) and renal failure (creatinine >150 µmol/l)
Cardiac dysfunction (ejection fraction <40)
Neurological disorder, myopathy, or history of psychological disorder (e.g. current treatment with antipsychotic and antidepressant medications)
Known sensitivity or contraindication to dugs used in the study
Preoperative opioid use or regular opioid use due to chronic pain (pain more than 3 months)
Preoperative administration of calcium channel blocker
Hypermagnesemia

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comulative morphine consumption. Timepoint: Baseline (before the operation), 4, 8, 12, 24 hours postoperatively. Method of measurement: Cumulative morphine consumption by assessing the patient controlled analgesia (PCA) pump.

Secondary Outcome Measures

Name	Time	Method
Visual analogue scale (VAS, 0-10) for pain at rest. Timepoint: Baseline (before the operation), 4, 8, 12, 24 hours postoperatively. Method of measurement: Visual analogue scale.;Posoperative nausea and vomiting (PONV). Timepoint: In 24 hours postoperatively. Method of measurement: Number of episodes patient experiencing nausea and vomiting.;Ramsay sedation scale (RSS). Timepoint: Baseline (before the operation), 4, 8, 12, 24 hours postoperatively. Method of measurement: Patients will be divided into 6 groups according to their level of sedation (from severe agitation to deep coma).