Cognitive Enhancement Through Model-based and Individualized Neurostimulation

Not Applicable

Recruiting

• Conditions: Transcranial Electrical Stimulation (tES)
• Interventions: Device: Transcranial electrical stimulation (tES) including SHAM

• Registration Number: NCT06235970
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The goal of this clinical trial is to learn about the effects of transcranial electric stimulation on attentional control and brain dynamics in healthy adults. The main questions are:

Does stimulation affect how subjects exert attentional control? Do mathematical models predict brain activity changes in response to stimulation?
...

Detailed Description

The purpose of this research is to compare the effects of different transcranial electrical stimulation (tES) protocols on both EEG and behavioral markers associated with attention and cognitive control. Both conventional tES protocols (tDCS, tACS) will be compared with customized stimulation waveforms derived from an individualized whole-brain neural model ...

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2023-12-06
• Study First Submitted QC: 2024-01-23
• Status Verified: 2024-02
• Study First Posted: 2024-02-01
• Study Start: 2024-02-13
• Last Update Submitted: 2024-02-14
• Last Update Posted: 2024-02-15
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• Healthy younger adults (ages 18 to 45). Community-living men, women or non-binary, aged 18-45

Exclusion criteria:

• Taking psychotropic medication or medication with cognitive side effects
• Medical disorder that affects cognitive or motor function
• Past/present head injury associated with loss of consciousness or neurological sequelae
• Prior occurrence of seizure of any origin
• Skin conditions affecting the scalp
• Scalp tattoos
• Rashes, sores or open wounds on scalp or face

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Device: Transcranial electrical stimulation (tES) including SHAM	Transcranial electrical stimulation (tES) including SHAM	healthy adults

Primary Outcome Measures

Name	Time	Method
EEG Markers	Assessed concurrently during each of two 1-hour experimental sessions	Spectral power at stimulation site and within target networks (frontoparietal, default mode): EEG oscillatory power in the beta frequency band over frontal electrodes and theta frequency power over midline electrodes during the delay and response periods, averaged over trial-types. We will also measure the difference in posterior alpha power between the Acue...

Secondary Outcome Measures

Name	Time	Method
Cognitive task accuracy	Assessed concurrently during each of two 1-hour experimental sessions	Percentage of correct responses in the BX and AY trial types for the during AX-CPT task
Cognitive task speed	Assessed concurrently during each of two 1-hour experimental sessions	Time taken by participants to respond in the BX and AY trial types for the AX-CPT task

Trial Locations

Locations (1)

Washington University; 🇺🇸 Saint Louis, Missouri, United States