Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia

Completed

• Conditions: Sickle Cell Disease; Thalassemia
• Interventions: Other: Medical Chart Summary

• Registration Number: NCT00972231
• Lead Sponsor: HaEmek Medical Center, Israel

Brief Summary

Iron overload impaired growth in Thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle Cell Anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients.

Growth velocity was not systematically studied in patients with Iron Overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. In Sickle Cell Patients this issue was not studied.

The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major and Intermedia patients and compare the results to another group of Sickle Cell patients, including Sickle cell thalassemia.

Detailed Description

Growth velocity, endocrine function and iron overload status will be studied in the patients that are in follow up at the Pediatric Hematology Unit, at the Ha'Emek Medical Center.

Patients who were lost from follow up or insufficient data about growth in the past will not included in the study.

Study Timeline

• Study Start: 2009-01
• Study First Submitted: 2009-09-03
• Study First Submitted QC: 2009-09-03
• Study First Posted: 2009-09-04
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-30
• Last Update Posted: 2015-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 93

Inclusion Criteria

• All patients in follow up with available medical charts.

Exclusion Criteria

• Patients lost from follow up or without enough data to calculate growth velocity or clinical and laboratory endocrine assessment or missing data about iron status.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sickle Cell Group	Medical Chart Summary	Patients with Sickle Cell Anemia and Sickle Cell Thalassemia
Thalassemia Group	Medical Chart Summary	Patients suffering from Thalassemia Major and patients with Thalassemia Intermedia

Primary Outcome Measures

Name	Time	Method
Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia	One year	Analysis of Growth Velocity in Thalassemia and Sickle Cell Anemia and correlation with Iron Overload

Trial Locations

Locations (1)

Pediatric Hematology Unit - Ha'Emek Medical Center; 🇮🇱 Afula, Israel