Genetic and Biological Background and Follow-up of Different Phenotypes of Coeliac Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Celiac Disease
- Sponsor
- Tampere University Hospital
- Enrollment
- 3500
- Locations
- 1
- Primary Endpoint
- Non-HLA variant association
- Status
- Recruiting
- Last Updated
- 7 months ago
Overview
Brief Summary
The main purpose of this study is to investigate genetic, serological, immunological and microbiata diversities between different coeliac disease phenotypes and to discover applicable prognostic markers for specific phenotypes.
Detailed Description
The recognition of clinical heterogeneity has expanded the understanding of coeliac disease, but the factors contributing to this diversity remain unclear. Moreover, since coeliac disease is highly heterogeneous, there is a need for more individualized follow-up and support and implementation of more personalized follow-up guidelines. In this study coeliac disease and dermatitis herpetiformis patients and healthy controls will be recruited. Genetic, clinical, immunological, micobiata and novel biomedical markers are compared between coeliac disease phenotypes and also controls and their prognostic value is assessed.
Investigators
Teea Salmi
Professor in Dermatology
Tampere University Hospital
Eligibility Criteria
Inclusion Criteria
- •Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis
- •Cohort 3: friend or non-related family member of coeliac disease or dermatitis herpetiformis patient
Exclusion Criteria
- •Cohorts 1-3: Age \<18 years
- •Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis not confirmed
- •Cohort 3: coeliac disease or dermatitis herpetiformis diagnosis
Outcomes
Primary Outcomes
Non-HLA variant association
Time Frame: baseline
phenotype specific non-HLA variants
Secondary Outcomes
- microbiata(baseline)
- serum transglutaminase antibodies(baseline)
- quality of life measure(baseline)
- gastrointestinal symptoms(baseline)
- dietary adherence(baseline)