Genetic and Biological Background and Follow-up of Different Phenotypes of Coeliac Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,500
- 试验地点
- 1
- 主要终点
- Non-HLA variant association
研究概览
简要总结
The main purpose of this study is to investigate genetic, serological, immunological and microbiata diversities between different coeliac disease phenotypes and to discover applicable prognostic markers for specific phenotypes.
详细描述
The recognition of clinical heterogeneity has expanded the understanding of coeliac disease, but the factors contributing to this diversity remain unclear. Moreover, since coeliac disease is highly heterogeneous, there is a need for more individualized follow-up and support and implementation of more personalized follow-up guidelines.
In this study coeliac disease and dermatitis herpetiformis patients and healthy controls will be recruited. Genetic, clinical, immunological, micobiata and novel biomedical markers are compared between coeliac disease phenotypes and also controls and their prognostic value is assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis
- •Cohort 3: friend or non-related family member of coeliac disease or dermatitis herpetiformis patient
排除标准
- •Cohorts 1-3: Age <18 years
- •Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis not confirmed
- •Cohort 3: coeliac disease or dermatitis herpetiformis diagnosis
结局指标
主要结局
Non-HLA variant association
时间窗: baseline
phenotype specific non-HLA variants
次要结局
- microbiata(baseline)
- serum transglutaminase antibodies(baseline)
- quality of life measure(baseline)
- gastrointestinal symptoms(baseline)
- dietary adherence(baseline)
研究者
Teea Salmi
Professor in Dermatology
Tampere University Hospital