Taste Physiology in Healthy, Normal-weight Volunteers
Not Applicable
Completed
- Conditions
- Exploratory Behavior
- Interventions
- Dietary Supplement: Single intragastric instillation of 200 mL tap water via nasogastric tubeDietary Supplement: Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tubeDietary Supplement: Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tubeDietary Supplement: Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tubeDietary Supplement: Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tubeDietary Supplement: Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube
- Registration Number
- NCT02255812
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
- right-handed healthy males
- Body-mass index of < 25
- Age 18-45 years
- no drugs
- non-smoking
Exclusion Criteria
- Smoking
- Substance abuse
- Regular intake of medications (except for oral contraceptives)
- Medical or psychiatric illness, especially: diabetes, pace-maker, claustrophobia
- History of gastrointestinal disorders
- Food allergies, glutamate intolerance
- Body piercings that cannot be removed
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 200 mL tap water Single intragastric instillation of 200 mL tap water via nasogastric tube Single intragastric instillation of 200 mL tap water via nasogastric tube 2 g citric acid Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube 2 g salt Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube 0.017 g quinine Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube 25 g glucose Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube 1 g monosodium glutamate Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube
- Primary Outcome Measures
Name Time Method regional brain activity assessed by functional Magnetic Resonance Imaging (fMRI) changes from baseline to one hour after treatment Changes in resting state functional connectivity
- Secondary Outcome Measures
Name Time Method gastrointestinal satiation peptide secretion changes from baseline to one hour after treatment Unit of Measure: glucagon like peptide-1 (GLP-1) in pg/mL, peptide tyrosine tyrosine (PYY) in pg/mL and gastric inhibitory polypeptide (GIP) in pg/mL
glucose and insulin secretion changes from baseline to one hour after treatment Unit of Measure: glucose in mmol/L, insulin in μU/mL
Trial Locations
- Locations (1)
University Hospital
🇨🇭Basel, Switzerland