CTRI/2025/09/094211尚未招募4 期
Randomized double-blind controlled trial comparing the analgesic effect of Dexamethasone versus Clonidine as adjuvants to 0.5% Levobupivacaine in ultrasound-guided supraclavicular brachial plexus block in patients undergoing upper limb surgery at SMS Medical College, Jaipur.”
SMS Medical College Jaipur1 个研究点 分布在 1 个国家目标入组 66 人开始时间: 2025年11月1日最近更新:
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- Duration of analgesia: Time from block administration to first rescue analgesia (minutes)
研究概览
简要总结
A prospective randomized double blind clinical study to compare the analgesic and anesthetic efficacy of Dexamethasone versus Clonidine as adjuvents to 0.5% Levobupivacain in ultrasound guided supraclavicular brachial plexus block in patients undergoing upper limb surgery. Primary outcome is total dural of analgesia, with secondary outcomes including onset/duration of sensory and motor block,hemodynamic changes and adverse events.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Double
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status I or II Weight 50–80 kg Patients undergoing upper limb surgery under supraclavicular block Written informed consent provided.
排除标准
- •Allergy to study drugs (local anesthetic, dexamethasone, clonidine) Coagulopathy or anticoagulant therapy Local infection at injection site Psychiatric illness or anxiety Respiratory illness/compromise Peripheral neuropathy or suspected compartment syndrome Participation in another trial.
结局指标
主要结局
Duration of analgesia: Time from block administration to first rescue analgesia (minutes)
时间窗: Continuously monitored postoperatively; recorded up to 24 hours after block
次要结局
- Onset of sensory block(Time Point: Assessed at 0, 2, 5, 10, 15, 20, and 30 minutes after block administration)
- Duration of sensory block(Monitored until regression; recorded up to 24 hours postoperatively)
- Onset of motor block(Assessed at 0, 10, 20, and 30 minutes after block administration)
- Duration of motor block(Monitored until regression; recorded up to 24 hours postoperatively)
- Adverse effects(Intraoperative and up to 24 hours postoperatively)
研究者
Dr Payal Mittal
Department of Anaesthesiology and Critical Care, SMS Medical College & Attached Hospitals, Jaipur
研究点 (1)
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