The effect of Body temperature regulation on host response in patients with Septic shock (A sub-study of the CASS study)

Completed

• Conditions: blood poisening; Septic shock; 10005908; 10004018

• Registration Number: NL-OMON44527
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 78

Inclusion Criteria

Patients who have been included in the CASS trial
Healthy volunteers: 18 years or older

Exclusion Criteria

- No informed consent for the substudy
- A platelet count < 10 x 10^9 /L
- Known mitochondrial disease
- Patient received platelet transfusion less than 6 hours before blood samples are taken

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Metabolism: Mitochondrial 02 consumption<br /><br>Circulation: Sublingual microcirculatory flow index<br /><br>Inflammation: Total amount of circulating microparticles<br /><br>Lung injury: total protein and inflammation markers in NBL</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>ICU-AW: MRC score</p><br>