The repair of early tooth decay after rinsing with two solutions, one containing fluoride and a major component of milk called casein, and another containing fluoride only.
Not Applicable
Completed
- Conditions
- Early (subsurface) enamel cariesOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12607000653460
- Lead Sponsor
- The University of Melbourne
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
Adults in good general and dental health
Have at least 22 teeth
Produce normal amounts of saliva (determined by measuring the volume of a two-minute unstimulated saliva sample and a two-minute stimulated saliva sample).
Exclusion Criteria
Allergic or adverse reactions to milk or milk products.
History of dry mouth, or medical conditions or taking medication likely to cause xerostomia.
Bleeding disorders.
Infectious diseases including blood-borne diseases such as HIV/AIDS; or Hepatitis C.
Active dental caries or periodontal diseases.
History of rheumatic heart disease, heart murmurs, etc. where risk of complications following bacteremia is present.
pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Remineralization of artificially-created subsurface carious lesions measured by calculating the difference in mineral content in lesions exposed to the solutions and the mineral content of the respective control lesions (not exposed to the solutions), using microdensitometric analysis of microradiographic images of the lesions.[Mineral content will be measured once at the end of 10 days' rinsing with each of the two solutions.]
- Secondary Outcome Measures
Name Time Method /A[N/A]