TCTR20180925004RecruitingPhase 2
High dose vitamin C as an adjuvant therapy in patient with septic shock
Bhumibol Adulyadej Hospital Fund0 sites60 target enrollmentStarted: September 25, 2018Last updated:
Conditions
Trial Snapshot
- Phase
- Phase 2
- Status
- Recruiting
- Sponsor
- Enrollment
- 60
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 Years to 80 Years (—)
- Sex
- All
Inclusion Criteria
- •1. Age over 18 year-old and less than 80 year-old
- •2. Septic shock is diagnosed in ER. (SIRS criteria ≥2 or qSOFA ≥2, require vasopressor for keeping MAP > 65 mmHg and serum lactate > 2 mmol/L)
Exclusion Criteria
- •1. Can not start intervention within 24 hours after septic shock is diagnosed
- •2. Prior antioxidant use eg. N-acetylcysteine, vitamin E, selenium, coenzyme Q10
- •3. There are contraindications for intravenous vitamin C (Allergic to vitamin C, bilateral ureteric obstruction, chronic hemodialysis, iron overload, oxalate stone former, hemochromatosis, G6PD deficiency and sickle cell disease)
- •4. Pregnant or breastfeeding woman
- •5. Patient who survives following CPR
- •6. Palliative care patients
- •7. Patients who will be enrolled in this study previously.
- •8. Patients who will be enrolled in other drug trials within 30 days before enrolment in this study
Investigators
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