NCT02201134已完成不适用
SEVOflurane Inhalation in CARdiac Arrest Resuscitated Patients Treated With Therapeutic Hypothermia
University Hospital, Clermont-Ferrand1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2014年7月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Determination of the feasibility of a sedation with inhalated sevoflurane in cardiac arrest resuscitated patients
研究概览
简要总结
Studying the feasibility of an initial sedation with inhalated sevoflurane during therapeutic hypothermia of cardiac arrests resuscitated patients.
详细描述
Prospective clinical study in ICU with ventilated patients sedated with sevoflurane using the Mirus® and Anaconda® , establishing the feasibility of an initial sedation of patients resuscitated from cardiac arrest and treated with therapeutic hypothermia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •-Adult patients ventilated requiring therapeutic hypothermia in ICU
- •Stable respiratory and hemodynamic conditions
- •Epinephrine and norepinephrine infusion rate < 1,5 g/kg/min
- •Consent of patients or family
- •Arterial line
- •Patients resuscitated after cardiac arrest
- •No Flow < 10 min
- •Low Flow < 20 min
- •Neutropenia < 1 G/L
- •Post traumatic cardiac arrest
- •Contraindication of halogenated anesthesics
- •Extra corporeal life support or intra aortic balloon pump
排除标准
- •-Pregnant woman
- •Hemodynamic instability
- •Brain death defined by the disappearance of brain stem reflexes
研究组 & 干预措施
sevoflurane
Other
干预措施: sevoflurane (Drug)
结局指标
主要结局
Determination of the feasibility of a sedation with inhalated sevoflurane in cardiac arrest resuscitated patients
时间窗: at day 1
The feasibility is evaluated by the number of side effects due to treatment until discharge from hospital.
次要结局
- Determination of systemic complications and organ failures during hospitalisation(at day 1)
- Determination of neurological prognostic of patients at ICU and hospital discharge(at day 1)
- Evaluation of systemic inflammation and evolution with cytokines(at day 1)
- Evaluation of markers specific of brain ischemia (S100 protein and neuron-specific enolase)(at day 1)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Inhalative Sedation in ICU With Sevoflurane Via Anaesthetic Conserving Device Compared to PropofolRecovery From SedationSevoflurane ConsumptionRenal FunctionHepatic FunctionCardioprotectionNCT00586118Klinikum Ludwigshafen120
已完成
3 期
SEvoflurane for Sedation in ARdsAcute Respiratory Distress SyndromeNCT04235608University Hospital, Clermont-Ferrand700
已完成
不适用
Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary BypassCardiac On-pump SurgeryNCT00924222University of Zurich120
已完成
不适用
Cardioprotection by Sevoflurane Preconditioning in Noncardiac Thoracic SurgeryHigh Sensitive Troponin T ReleaseNCT02217319Dr. Horst Schmidt Klinik GmbH100
已完成
3 期
Sevoflurane in COVID-19 ARDS (SevCov)ARDS, HumanCoronavirusNCT04355962University of Zurich68