Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

Not Applicable

Completed

• Conditions: Cardiac On-pump Surgery
• Interventions: Drug: Sevoflurane; Drug: Propofol

• Registration Number: NCT00924222
• Lead Sponsor: University of Zurich

Brief Summary

Organ protection, volatile anesthetics, postconditioning.

Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ function and inflammatory mediators in the blood.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-10
• Study First Submitted: 2009-06-17
• Study First Submitted QC: 2009-06-17
• Study First Posted: 2009-06-18
• Primary Completion: 2009-11
• Study Completion: 2009-12
• Status Verified: 2011-10
• Last Update Submitted: 2011-10-11
• Last Update Posted: 2011-10-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Propofol	-
Propofol	Sevoflurane	-
Sevoflurane	Sevoflurane	-
Propofol	Propofol	-

Primary Outcome Measures

Name	Time	Method
Myocardial injury markers (myoglobin, creatine kinase, myocard specific creatine kinase, and troponin T)	Start and end of ICU stay

Secondary Outcome Measures

Name	Time	Method
Oxygenation index, postoperative pulmonary complications, ICU stay (days), length of hospitalisation	Start with surgery until end of hospitalisation