NCT01905501
Completed
Not Applicable
Sevoflurane Protective Effect on Ischemia-reperfusion Injury in Patients Undergoing Reconstructive Plastic Surgery With Microsurgical Flap. Multicenter, Randomized Controlled Trial.
ConditionsMicrosurgical Free Flaps
Overview
- Phase
- Not Applicable
- Intervention
- Total intravenous anesthesia
- Conditions
- Microsurgical Free Flaps
- Sponsor
- Regina Elena Cancer Institute
- Enrollment
- 132
- Locations
- 1
- Primary Endpoint
- continuous tissue oximetry (NIRS)
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
This study aimed to evaluate the possible protective effect of anesthetic technique balanced(with sevoflurane) compared with total intravenous anesthetic technique (propofol,remifentanil). The hypothesis is that the Sevoflurane may exert protective effect in regard to the ischemia-reperfusion injury induced on the microsurgical breast free flap during transfer to receiving area. The investigators will evaluate the continuous flap tissue oximetry and the level of biochemical markers.
Investigators
Ester Forastiere
M.D., Chief of Critical Area Department
Regina Elena Cancer Institute
Eligibility Criteria
Inclusion Criteria
- •Patient selected for plastic breast surgery With microsurgical Free flap Over 18 y Asa I/II
Exclusion Criteria
- •Unusual reaction to anesthetic drugs Suspect for malignant hyperthermia Vasculopathic disease Coagulation disease
Arms & Interventions
Total intravenous anesthesia
Total intravenous anaesthesia
Intervention: Total intravenous anesthesia
Balanced anesthesia
Intervention: Balanced anesthesia
Outcomes
Primary Outcomes
continuous tissue oximetry (NIRS)
Time Frame: 20 hours
Secondary Outcomes
- Biochemical Markers(Preoperative and 24 hours post operative)
- Lactate Clearance(24 hours)
Study Sites (1)
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