Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers

University of Zurich1 site in 1 country10 target enrollmentJanuary 2005

ConditionsIschemia/Reperfusion Injury

DrugsSevoflurane (Preconditioning)

Overview

Phase: Phase 4
Intervention: Not specified
Conditions: Ischemia/Reperfusion Injury
Sponsor: University of Zurich
Enrollment: 10
Locations: 1
Primary Endpoint: marker expression on blood cells
Last Updated: 17 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury.

Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation

Detailed Description

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations. Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

Registry

clinicaltrials.gov

Start Date

January 2005

End Date

December 2008

Last Updated

17 years ago

Study Type

Interventional

Study Design

Crossover