Sevoflurane Protective Effect on Ischemia Reperfusion Injury in Microvascular Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Sevoflurane
- Conditions
- Microvascular Breast Flap in Plastic Surgery
- Sponsor
- Regina Elena Cancer Institute
- Enrollment
- 128
- Locations
- 1
- Primary Endpoint
- tissutal oximetry average value of the flap measured with INVOS (In Vivo Optical Spectroscopy) system continuously.
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
This study aimed to evaluate the possible protective effect of anesthetic technique balanced (BAL) compared to total intravenous anesthetic technique (TIVA-TCI) in ischemia reperfusion injury in microvascular flap in plastic surgery. The investigators will evaluate the viability of the flap using tissue oximetry monitoring and the level of biochemical markers in a circle at the end of the intervention.
Investigators
Ester Forastiere
director
Regina Elena Cancer Institute
Eligibility Criteria
Inclusion Criteria
- •age \> 18 yr
- •ASA (American Society of Anesthesiology) I-II
Exclusion Criteria
- •Known unusual reaction to anesthetic drugs
- •Evaluation of anesthesia increased risk for malignant hyperthermia.
- •History of vascular disease.
- •History of bleeding diathesis.
Arms & Interventions
Bilanced group
Sevofluorane adjusted to obtain an Et-Sevo of 1.8-2%, for all the time of the surgical procedure. Remifentanyl TCI adjusted according to protocol to maintain the range of 1-3 ng / ml.
Intervention: Sevoflurane
TCI group
Propofol 3-4 mg / ml and remifentanyl 1-3 ng / ml according to protocol TCI
Intervention: Diprivan + Remifentanil TCI
Outcomes
Primary Outcomes
tissutal oximetry average value of the flap measured with INVOS (In Vivo Optical Spectroscopy) system continuously.
Time Frame: 24 hours from the end of intervention