The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery
Not Applicable
- Conditions
- Brain Ischemia
- Interventions
- Procedure: Sevo continuous inhalationProcedure: Sev-I group
- Registration Number
- NCT01204268
- Lead Sponsor
- Xijing Hospital
- Brief Summary
The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.
- Detailed Description
The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Patient under intracranial aneurysm surgery.
Exclusion Criteria
- Patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, Alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sevo-C group Sevo continuous inhalation Patients will receive the anesthesia with continuous inhalation of sevoflurane. Sevo-I group Sev-I group Sevoflurane will be given before the cerebral artery clip as a preconditioning procedure for the coming ischemia-reperfusion injury.
- Primary Outcome Measures
Name Time Method S-100B,NSE 7 days
- Secondary Outcome Measures
Name Time Method Karnofsky Performance Scale,NIH stroke index, MMSE 6 months
Trial Locations
- Locations (1)
Xijing Hospital
🇨🇳Xi'an, Shaanxi, China