The Neuroprotection of Sevoflurane Preconditioning on Intracranial Aneurysm Surgery

Not Applicable

• Conditions: Brain Ischemia

• Registration Number: NCT01204268
• Lead Sponsor: Xijing Hospital

Brief Summary

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.

Detailed Description

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.

Study Timeline

• Status Verified: 2009-08
• Study Start: 2009-08
• Study First Submitted: 2010-09-15
• Study First Submitted QC: 2010-09-15
• Last Update Submitted: 2010-09-16
• Study First Posted: 2010-09-17
• Last Update Posted: 2010-09-20
• Primary Completion: 2011-08
• Study Completion: 2011-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patient under intracranial aneurysm surgery.

Exclusion Criteria

• Patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, Alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
S-100B,NSE	7 days

Secondary Outcome Measures

Name	Time	Method
Karnofsky Performance Scale,NIH stroke index, MMSE	6 months

Trial Locations

Locations (1)

Xijing Hospital; 🇨🇳 Xi'an, Shaanxi, China