The Neuroprotection of Sevoflurane Preconditioning on Perioperative Ischemia-reperfusion Injury During Intracranial Aneurysm Surgery

Xijing Hospital1 site in 1 country80 target enrollmentAugust 2009

ConditionsBrain Ischemia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Brain Ischemia
Sponsor: Xijing Hospital
Enrollment: 80
Locations: 1
Primary Endpoint: S-100B,NSE
Last Updated: 15 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery.

Detailed Description

The current study is designed to clarify the neuroprotective effect of sevoflurane preconditioning on the patients underwent intracranial aneurysm surgery. The patients with cerebral aneurysm will be recruited in current study. The sevoflurane preconditioning will be performed before the surgical procedure. The neurological injury biomarkers, such as S-100b and NSE will be detected. The neurological function and recovery will be assessed after the surgery.

Registry

clinicaltrials.gov

Start Date

August 2009

End Date

October 2011

Last Updated

15 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Xijing Hospital

Eligibility Criteria

Inclusion Criteria

•Patient under intracranial aneurysm surgery.

Exclusion Criteria

•Patients who refused to participate or who had a history of chemotherapy/convulsions two weeks prior to admission, stroke/cardiopulmonary resuscitation/head trauma three months prior to admission, Alzheimer's disease, amyotrophic lateral sclerosis, and prior melanoma were excluded.