Effect of Sevoflurane-induced Postconditioning on the Incidence of Postoperative Cerebral Hyperperfusion Syndrome After Revascularization Surgery in Adult Patients With Moyamoya Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 152
- 主要终点
- The incidence of postoperative cerebral hyperperfusion syndrome
研究概览
简要总结
The aim of the present study is to evaluate the effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome following revascularization surgery in moyamoya patients.
详细描述
Postoperative hyperperfusion syndrome is a common complication in moyamoya disease patients receiving revascularization surgery. Previously its incidence has been reported to be 17~50%, but little remains regarding frequency of reperfusion injury after revascularization surgery in patients with moyamoya disease. Volatile anesthetics such as sevoflurane has been introduced clinically to reduce reperfusion injury and preconditioning with sevoflurane induced ischemic tolerance like as ischemic preconditioning. However, there was no report on the neuroprotective effect of sevoflurane postconditioning on ischemic/reperfusion injury in human brain. Therefore, We evaluated the neuroprotective effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome after revascularization surgery in moyamoya disease patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients receiving cerebral revascularization surgery due to moyamoya disease
排除标准
- •Patients who do not agree to the study
- •Patients with uncontrolled diabetes or hypertension
- •Patients using cyclooxygenase2 inhibitor or with previously using cyclooxygenase2 inhibitor
- •Patients with acute renal failure
- •Patients with previous intervention related with moyamoya disease
研究组 & 干预措施
Sevo_postconditioning
Patients receiving sevoflurane 1.0 minimum alveolar concentration (MAC) for 30 minutes after revascularization competed.
干预措施: Sevoflurane (Drug)
结局指标
主要结局
The incidence of postoperative cerebral hyperperfusion syndrome
时间窗: postoperative day 15
Cerebral hyperperfusion syndrome was defined if all the following four criteria were met: i) new development of postoperative focal neurological deficits, ii) a delayed neurological deficits which were not shown in the immediate postoperative period; iii) postoperative reversible neurological deficits which were completely resolved within 15 days after operation; iii) neither definite haematomas nor definite acute infarction on a brain CT scan, on diffusion magnetic resonance imaging, or both.
次要结局
- The incidence of a new onset postoperative cerebral ischemia(participants will be followed for the duration of hospital stay, an expected average of 3 weeks.)
- The incidence of a new onset postoperative brain hematoma(participants will be followed for the duration of hospital stay, an expected average of 3 weeks.)
- The incidence of unrecovered neurological deficit(participants will be followed for the duration of hospital stay, an expected average of 3 weeks.)
研究者
Hee-Pyoung Park
Associate Professor
Seoul National University Hospital