Does a Sevoflurane Preconditioning Have Cardioprotective Properties in Noncardiac Thoracic Surgery?
Overview
- Phase
- N/A
- Intervention
- Sevoflurane
- Conditions
- High Sensitive Troponin T Release
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Troponin T
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
It has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties. This has been shown in animal studies and in patients that underwent cardiac surgery. The aim of our study is to examine if Sevoflurane, a volatile anaesthetic, has this properties in patients undergoing lung surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Lung surgery
- •ASA (American Society of Anesthesiologists) physical status 1-3
Exclusion Criteria
- •Disposition for malignant hyperthermia
- •Medication with ß-blocking drugs
- •Use of clonidin
Arms & Interventions
Sevoflurane
Patients receive Sevoflurane 1 MAC (minimal alveolar concentration) after induction of anesthesia with propofol, remifentanil and atracurium for 30 minutes as preconditioning.
Intervention: Sevoflurane
TIVA
Patients received the standard total intravenous anesthesia (TIVA) with propofol, remifentanil and atracurium.
Intervention: TIVA
Outcomes
Primary Outcomes
Troponin T
Time Frame: change of Troponin T levels preoperative and postoperative up to 40 hours after surgery
assessing a change in high sensitive Troponin T (5th generation) Level before and at six time points after surgery (right after surgery, every 8 hours up to 40 hours after surgery)