A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
- Conditions
- Crohn's Disease
- Interventions
- Registration Number
- NCT03105128
- Lead Sponsor
- AbbVie
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active Crohn's disease (CD).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 931
- Male or female aged >=18 to <= 80 years, or minimum age of adult consent according to local regulations, at the Baseline Visit. Where locally permissible, participants 16 to < 18 years of age who meet the definition of Tanner stage 5 for development at the Baseline Visit.
- Diagnosis of CD for at least 3 months prior to Baseline.
- Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score, and Simple Endoscopic Score for Crohn's Disease (SES-CD).
- Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD.
- If female, participant must meet the contraception recommendations.
- Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
- Participants with unstable doses of concomitant Crohn's disease therapy.
- Receipt of Crohn's disease approved biologic agents (infliximab, adalimumab, certolizumab, vedolizumab, natalizumab within 8 weeks prior to Baseline or ustekinumab within 12 weeks prior to Baseline), or any investigational biologic or other agent or procedure within 35 days or 5 half-lives prior to Baseline, whichever is longer.
- Prior exposure to p19 inhibitors (e.g., risankizumab).
- Complications of Crohn's disease.
- Having an ostomy or ileoanal pouch.
- Known active Coronavirus Disease 2019 (COVID-19) infection.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Risankizumab Dose 2 (Period 1) risankizumab IV Participants randomized to receive risankizumab dose 2 administered by intravenous (IV) infusion. Risankizumab Dose 2 (Period 2) risankizumab SC Participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 2 administered by subcutaneous (SC) injection in Period 2. Risankizumab Dose 1 (Period 1) risankizumab IV Participants randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion. Risankizumab Dose 3 (Period 2) risankizumab SC Participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 3 administered by subcutaneous (SC) injection in Period 2. Placebo (Period 1) placebo for risankizumab Participants randomized to receive placebo for risankizumab administered by intravenous (IV) infusion. Risankizumab Dose 1 (Period 2) risankizumab IV Participants who received placebo in Period 1 and participants with inadequate response at Week 12 in Period 1 randomized to receive risankizumab dose 1 administered by intravenous (IV) infusion in Period 2.
- Primary Outcome Measures
Name Time Method US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission Week 12 The CDAI consists of 8 components; 7 are based on participant diary entries, participant interviews, physical examinations, measurement of body weight and height and 1 is based on laboratory analysis. CDAI clinical remission of Crohn's disease is defined as CDAI \< 150.
Global Outside of US: Percentage of Participants With Clinical Remission Week 12 Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
Global Outside of US: Percentage of Participants With Endoscopic Response Week 12 The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic response is defined as a decrease in SES-CD \> 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
US Specific: Percentage of Participants With Endoscopic Response Week 12 The SES-CD assesses endoscopic disease severity by evidence of active intestinal mucosal inflammation. Endoscopic response is defined as a decrease in SES-CD \> 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
- Secondary Outcome Measures
Name Time Method US Specific: Percentage of Participants With Clinical Remission Week 12 Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
US Specific: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline Week 12 Participants without draining fistulas at Week 12 in participants who had draining fistulas at baseline.
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission Week 4 Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical remission of Crohn's disease is defined as CDAI \< 150.
US Specific: Percentage of Participants With Stool Frequency (SF) Remission Week 12 Stool Frequency (SF) remission is defined as an average daily SF \<= 2.8 and not worse than baseline.
Global Outside of US: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Week 12 The FACIT-Fatigue scale is a 13-item tool that measures an individual's level of fatigue during their usual daily activities over the past 7 days. Each of the fatigue and impact of fatigue items are measured on a four point Likert scale. The FACIT Fatigue Scale is the sum of the individual 13 scores and ranges from 0 to 52 where higher scores indicate better the quality of life. A positive change from baseline indicates improvement.
Global Outside of US: Change From Baseline in Work Productivity and Impairment Questionnaire - Crohn's Disease (WPAI-CD) Overall Work Impairment Week 12 WPAI: CD is a questionnaire used to evaluate lost productivity due to CD ; scores are presented as percentages (multiplying the scores by 100), with 0% representing no impact on productivity and 100% representing complete impact on productivity. Total work productivity impairment takes into account both hours missed due to CD symptoms and the patient's assessment of the degree to which CD affected their productivity while working (overall work impairment \[OWI\]). WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity.
Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission Week 12 The CDAI consists of 8 components; 6 are based on participant diary entries, participant interviews, and physical examinations, and 2 are based on laboratory analysis, and measurement of body weight and height. CDAI clinical remission of Crohn's disease is defined as CDAI \< 150.
US Specific: Percentage of Participants With Endoscopic Remission Week 12 Endoscopic remission: SES-CD ≤ 4 and at least a 2 point reduction versus baseline and no subscore greater than 1 in any individual variable
US Specific: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at Week 12 Manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.
US Specific: Percentage of Participants With CD-Related Hospitalization Week 12 Participants with at least one admission to the hospital due to Crohn's Disease.
US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response Week 12 Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
US Specific: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Week 12 The FACIT-Fatigue scale is a 13-item tool that measures an individual's level of fatigue during their usual daily activities over the past 7 days. Each of the fatigue and impact of fatigue items are measured on a four point Likert scale. The FACIT Fatigue Scale is the sum of the individual 13 scores and ranges from 0 to 52 where higher scores indicate better the quality of life. A positive change from baseline indicates improvement.
US Specific: Percentage of Participants With CDAI Clinical Response and Endoscopic Response Week 12 Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
Endoscopic response was a decrease in Simplified Endoscopic Score for Crohn's Disease (SES-CD) \> 50% from Baseline (or for subjects with isolated ileal disease and a Baseline SES-CD of 4, at least a 2 point reduction from Baseline).US Specific: Percentage of Participants With Abdominal Pain (AP) Remission Week 12 The Abdominal Pain rating is an assessment that is graded from 0 to 3: 0= None, 1= Mild, 2= Moderate and 3= Severe. AP remission is defined as average daily AP score \<= 1 and not worse than baseline.
US Specific: Percentage of Participants With Enhanced Clinical Response Week 12 Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response Week 12 Crohn's Disease Activity Index (CDAI) is used to assess the symptoms of participants with Crohn's Disease. Higher CDAI scores indicate more severe disease. CDAI clinical response is defined as reduction of CDAI ≥ 100 points from baseline.
US Specific: Percentage of Participants With Ulcer-Free Endoscopy Week 12 Ulcer-free endoscopy: SES-CD ulcerated surface subscore of 0 in subjects with SES-CD ulcerated surface subscore ≥ 1 at Baseline
Global Outside of US: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score Week 12 The IBDQ is a 32-item (ranges 1 - 7) self-report questionnaire for patients with IBD to evaluate the patient reported outcomes across 4 dimensions: bowel symptoms (loose stools, abdominal pain), systemic symptoms (fatigue, altered sleep pattern), social function (work attendance, need to cancel social events), and emotional function (anger, depression, irritability). The IBDQ total Score ranges from 32 to 224 with a higher score indicating better outcome.
Global Outside of US: Percentage of Participants With Enhanced Clinical Response Week 12 Enhanced clinical response: ≥ 60% decrease in average daily SF and/or ≥ 35% decrease in average daily AP score and both not worse than Baseline, and/or clinical remission
Global Outside of US: Percentage of Participants With Ulcer-Free Endoscopy Week 12 Ulcer-free endoscopy: SES-CD ulcerated surface subscore of 0 in subjects with SES-CD ulcerated surface subscore ≥ 1 at Baseline
Global Outside of US: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at Baseline Week 12 Manifestations of Crohn's disease in areas of the body other than the digestive tract, including eyes, skin, joints, mouth, and liver.
Global Outside of US: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline Week 12 Participants without draining fistulas at Week 12 in participants who had draining fistulas at baseline.
Global Outside of US: Percentage of Participants With Clinical Remission Week 4 Clinical remission is defined as using the average daily Stool Frequency (SF) ≤ 2.8 and not worse than Baseline AND average daily Abdominal Pain (AP) score ≤ 1 and not worse than Baseline.
Global Outside of US: Percentage of Participants With Enhanced Clinical Response and Endoscopic Response Week 12 Enhanced clinical response was defined as ≥ 60% decrease in average daily Stool Frequency and/or ≥ 35% decrease in average daily Abdominal Pain score and both not worse than baseline, and/or clinical remission. Endoscopic Response was defined as a decrease in Simplified Endoscopic Score for Crohn's Disease (SES-CD) \> 50% from Baseline (or for subjects with isolated ileal disease and a Baseline SES-CD of 4, at least a 2 point reduction from Baseline).
Global Outside of US: Percentage of Participants With Endoscopic Remission Week 12 Endoscopic remission: SES-CD ≤ 4 and at least a 2 point reduction versus baseline and no subscore greater than 1 in any individual variable
Global Outside of US: Percentage of Participants With CD-Related Hospitalization Week 12 Participants with at least one admission to the hospital due to Crohn's Disease.
Global Outside of US: Change From Baseline in Short Form-36 (SF-36) Physical Component Summary (PCS) Score Week 12 The Short Form-36 Health Survey determined participants' overall quality of life by assessing 1) limitations in physical functioning due to health problems; 2) limitations in usual role because of physical health problems; 3) bodily pain; 4) general health perceptions; 5) vitality; 6) limitations in social functioning because of physical or emotional problems; 7) limitations in usual role due to emotional problems; and 8) general mental health. Items 1-4 comprise the physical component of the SF-36. Scores on each item were summed and averaged (range = 0-100); a positive change from Baseline indicates improvement.
Trial Locations
- Locations (475)
The University of Chicago Medical Center /ID# 157141
🇺🇸Chicago, Illinois, United States
Children's Hospital of Pittsburgh of UPMC /ID# 210920
🇺🇸Pittsburgh, Pennsylvania, United States
Renmin Hospital of Wuhan University /ID# 214873
🇨🇳Wuhan, Hubei, China
Duplicate_Long Island Clinical Research /ID# 154836
🇺🇸Great Neck, New York, United States
TLC Clinical Research Inc /ID# 212503
🇺🇸Los Angeles, California, United States
SIH Research Mumtaz, Inc /ID# 163082
🇺🇸Kissimmee, Florida, United States
Southwest Gastroenterology /ID# 165002
🇺🇸Oak Lawn, Illinois, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 201848
🇺🇸Dallas, Texas, United States
Cleveland Clinic Main Campus /ID# 208171
🇺🇸Cleveland, Ohio, United States
Kanazawa University Hospital /ID# 201766
🇯🇵Kanazawa-shi, Ishikawa, Japan
Yamagata University Hospital /ID# 200154
🇯🇵Yamagata-shi, Yamagata, Japan
Hanyang University Guri Hospital /ID# 158673
🇰🇷Guri, Gyeonggido, Korea, Republic of
Severance Hospital /ID# 158671
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 213552
🇰🇷Daejeon, Korea, Republic of
Tvm Med Serv Srl /Id# 166294
🇷🇴Cluj, Romania
KM Management, spol. s.r.o. /ID# 206763
🇸🇰Nitra, Slovakia
GASTRO I., s.r.o. /ID# 156466
🇸🇰Presov, Slovakia
Hospital General Universitario Gregorio Maranon /ID# 161435
🇪🇸Madrid, Spain
Hospital Universitario La Paz /ID# 159228
🇪🇸Madrid, Spain
Hospital Clinico Universitario de Salamanca /ID# 157532
🇪🇸Salamanca, Spain
Hospital Universitario Basurto /ID# 205189
🇪🇸Bilbao, Vizcaya, Spain
Skane University hospital /ID# 211235
🇸🇪Malmo, Skane Lan, Sweden
Duplicate_GHP Stockholm Gastro Center /ID# 210479
🇸🇪Stockholm, Stockholms Lan, Sweden
CliniCore International, LLC /ID# 158209
🇺🇸Houston, Texas, United States
Baylor College of Medicine - Baylor Medical Center /ID# 158212
🇺🇸Houston, Texas, United States
Centex Studies, Inc. - Houston /ID# 200720
🇺🇸Houston, Texas, United States
Virginia Mason - Seattle Orthapedics /ID# 155545
🇺🇸Seattle, Washington, United States
Vista Health Research, LLC /ID# 212664
🇺🇸Miami, Florida, United States
Las Vegas Medical Research /ID# 160172
🇺🇸Las Vegas, Nevada, United States
Revival Research Institute, Inc /ID# 210984
🇺🇸Las Vegas, Nevada, United States
Atrium Health Carolinas Medical Center /ID# 158481
🇺🇸Charlotte, North Carolina, United States
Clinical Trials America /ID# 158484
🇺🇸Hickory, North Carolina, United States
University of California, San Francisco /ID# 157143
🇺🇸San Francisco, California, United States
Vanderbilt University Medical Center /ID# 157138
🇺🇸Nashville, Tennessee, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 161336
🇺🇸San Antonio, Texas, United States
Southern Star Research Institute, LLC /ID# 168770
🇺🇸San Antonio, Texas, United States
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161305
🇮🇹Negrar, Verona, Italy
Cotton-O'Neil Clinical Res Ctr /ID# 154738
🇺🇸Topeka, Kansas, United States
CHU UCL Namur - site Godinne /ID# 157401
🇧🇪Godinne, Namur, Belgium
St Vincent's University Hospital /ID# 157512
🇮🇪Elm Park, Dublin, Ireland
Plains Clinical Research Center, LLC /ID# 169715
🇺🇸Fargo, North Dakota, United States
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159321
🇩🇪Kiel, Schleswig-Holstein, Germany
Rocky Mountain Pediatric Gastroenterology /ID# 207169
🇺🇸Lone Tree, Colorado, United States
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210529
🇩🇪Saarbrücken, Saarland, Germany
Peak Gastroenterology Associates, PC /ID# 165834
🇺🇸Colorado Springs, Colorado, United States
Hospital de Clinicas de Porto Alegre /ID# 157653
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Universitario Puerta de Hierro, Majadahonda /ID# 157575
🇪🇸Majadahonda, Madrid, Spain
Groupe Sante CHC - Clinique du MontLegia /ID# 157393
🇧🇪Liege, Belgium
AZ-Delta /ID# 157391
🇧🇪Roeselare, Belgium
Vitebsk Regional Advanced Clin /ID# 159497
🇧🇾Витебск, Belarus
University Clinical Centre of the Republic of Srpska /ID# 157717
🇧🇦Banja Luka, Republika Srpska, Bosnia and Herzegovina
Universal Axon Clinical Research /ID# 165432
🇺🇸Doral, Florida, United States
Velocity Clinical Research - Salt Lake City /ID# 161781
🇺🇸West Jordan, Utah, United States
Clinical Center University of Sarajevo /ID# 165134
🇧🇦Sarajevo, Bosnia and Herzegovina
Duplicate_Mater Hospital /ID# 167990
🇦🇺South Brisbane, Queensland, Australia
Duplicate_Medical University of Vienna /ID# 158138
🇦🇹Vienna, Wien, Austria
Grodno city clinical hospital #2 /ID# 159499
🇧🇾Grodno, Belarus
Coral Research Clinic /ID# 158549
🇺🇸Miami, Florida, United States
CHU de Liege /ID# 157398
🇧🇪Liege, Belgium
UMHAT Sveti Ivan Rilski /ID# 204714
🇧🇬Sofia, Bulgaria
IWK Health Center /ID# 165900
🇨🇦Halifax, Nova Scotia, Canada
WVU Medicine /ID# 167940
🇺🇸Morgantown, West Virginia, United States
University Multiprofile Hospit /ID# 167575
🇧🇬Varna, Bulgaria
Gastroenterology Associates, P.A. of Greenville /ID# 154911
🇺🇸Greenville, South Carolina, United States
University Clinical Centre of the Republic of Srpska /ID# 164512
🇧🇦Banja Luka, Republika Srpska, Bosnia and Herzegovina
Imelda Ziekenhuis /ID# 157392
🇧🇪Bonheiden, Belgium
UMHAT Tsaritsa Joanna - ISUL /ID# 211240
🇧🇬Sofia, Bulgaria
Hospital Las Higueras /ID# 167090
🇨🇱Talcahuano, Chile
Shanghai East Hospital /ID# 212683
🇨🇳Pudong New District, China
Tianjin Medical University General Hospital /ID# 210927
🇨🇳Tianjin, China
Hospital Universitario San Vic /ID# 171487
🇨🇴Medellin, Colombia
North Estonia Medical Centre /ID# 163507
🇪🇪Tallinn, Estonia
Universitaetsklinikum Regensburg /ID# 163665
🇩🇪Regensburg, Germany
Tsujinaka Hospital Kashiwanoha /ID# 213847
🇯🇵Kashiwa-shi, Chiba, Japan
Universitaetsklinikum Tuebingen /ID# 159324
🇩🇪Tübingen, Baden-Wuerttemberg, Germany
University of Alberta - Zeidler Ledcor Centre /ID# 157098
🇨🇦Edmonton, Alberta, Canada
Duplicate_HOSPITAL CENTENARIO /ID# 170883
🇦🇷Rosario, Santa Fe, Argentina
QEII - Health Sciences Centre /ID# 157087
🇨🇦Halifax, Nova Scotia, Canada
Fraser Clinical Trials Inc /ID# 159053
🇨🇦New Westminster, British Columbia, Canada
Centro de Investigaciones Clínicas Viña del Mar /ID# 203589
🇨🇱Viña del Mar, Valparaíso, Chile
London Health Sciences Center /ID# 157160
🇨🇦London, Ontario, Canada
Gomel Regional Clinical Hospital /ID# 159498
🇧🇾Gomel, Belarus
Universitair Ziekenhuis Leuven /ID# 157396
🇧🇪Leuven, Vlaams-Brabant, Belgium
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157672
🇧🇷Goiânia, Goias, Brazil
MHAT Trakia /ID# 201672
🇧🇬Stara Zagora, Bulgaria
GIRI Gastrointestinal Research Institute /ID# 157095
🇨🇦Vancouver, British Columbia, Canada
HP Clinical Research /ID# 162998
🇺🇸Bountiful, Utah, United States
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157649
🇧🇷Ribeirão Preto, Sao Paulo, Brazil
Allen Whey Khye Lim Professional Corporation /ID# 169761
🇨🇦Edmonton, Alberta, Canada
Mount Sinai Hospital /ID# 169762
🇨🇦Toronto, Ontario, Canada
CISSS de la Monteregie /ID# 161615
🇨🇦Greenfield Park, Quebec, Canada
CHAU- Hotel-Dieu de Levis /ID# 214375
🇨🇦Levis, Quebec, Canada
Montreal General Hospital - McGill University Health Center /ID# 157084
🇨🇦Montreal, Quebec, Canada
Klinicki bolnicki centar Zagreb /ID# 157566
🇭🇷Zagreb, Grad Zagreb, Croatia
University Hospital Galway /ID# 157513
🇮🇪Galway, Ireland
Hadassah Medical Center-Hebrew University /ID# 165913
🇮🇱Jerusalem, Israel
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 155637
🇮🇹Palermo, Italy
Aichi Medical University Hospital /ID# 160159
🇯🇵Nagakute-shi, Aichi, Japan
NHO Fukuyama Medical Center /ID# 163578
🇯🇵Fukuyama-shi, Hiroshima, Japan
Yokohama Municipal Citizen's Hospital /ID# 204126
🇯🇵Yokohama-shi, Kanagawa, Japan
Sykehuset Levanger Helse NT /ID# 157885
🇳🇴Levanger, Norway
Centrum Medyczne Medyk /ID# 212889
🇵🇱Rzeszów, Podkarpackie, Poland
Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160739
🇵🇹Guimaraes, Braga, Portugal
Hospital Univ San Ignacio /ID# 158733
🇨🇴Bogota, Cundinamarca, Colombia
East Tallinn Central Hospital /ID# 157076
🇪🇪Tallinn, Harjumaa, Estonia
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157428
🇬🇷Athens, Greece
Tokatsu Tsujinaka Hospital /ID# 163362
🇯🇵Abiko-shi, Chiba, Japan
Chiba University Hospital /ID# 217532
🇯🇵Chiba-shi, Chiba, Japan
Asahikawa Medical University Hospital /ID# 162844
🇯🇵Midorigaokahiga-shi, Hokkaido, Japan
Sapporo Medical University Hospital /ID# 163028
🇯🇵Sapporo-shi, Hokkaido, Japan
Riga East Clinical University Hospital /ID# 159613
🇱🇻Riga, Latvia
Gastromed /Id# 212099
🇵🇱Torun, Kujawsko-pomorskie, Poland
Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160715
🇵🇹Faro, Portugal
Centro Hosp de Tondela-Viseu /ID# 160697
🇵🇹Viseu, Portugal
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156465
🇸🇰Banska Bystrica, Slovakia
Inselspital, Universitätsspital Bern /ID# 163531
🇨🇭Bern, Switzerland
Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 212050
🇺🇦Kherson, Ukraine
Medical Center of LLC Medbud-Clinic /ID# 216929
🇺🇦Kyiv, Ukraine
Praxiszentrum fuer Gastroenterologie /ID# 211964
🇩🇪Grevenbroich, Nordrhein-Westfalen, Germany
Nagoya City University Hospital /ID# 160162
🇯🇵Nagoya shi, Aichi, Japan
Toho University Sakura Medical Center /ID# 160161
🇯🇵Sakura-shi, Chiba, Japan
Duplicate_Hospital of lithuanian university of Health Science Kauno Klinikos /ID# 162582
🇱🇹Kaunas, Lithuania
Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 163654
🇲🇾Kuala Lumpur, Selangor, Malaysia
Academisch Medisch Centrum /ID# 157950
🇳🇱Amsterdam, Netherlands
The Jikei University Hospital /ID# 163190
🇯🇵Minato-ku, Tokyo, Japan
Hospital Beatriz Ângelo /ID# 207757
🇵🇹Loures, Portugal
Cabinet Particular Policlinic Algomed /ID# 163047
🇷🇴Timișoara, Romania
Novosibirski Gastrocenter /ID# 217554
🇷🇺Novosibirsk, Russian Federation
Clinical Hosp Center Zvezdara /ID# 156978
🇷🇸Belgrade, Beograd, Serbia
Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 210856
🇨🇳Wuhan, Hubei, China
Duplicate_Kitasato University Kitasato Institute Hospital /ID# 160144
🇯🇵Minato-ku, Tokyo, Japan
Asan Medical Center /ID# 158678
🇰🇷Seoul, Korea, Republic of
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211038
🇨🇳Wuhan, Hubei, China
Jinhua Municipal Central Hospital /ID# 215626
🇨🇳Jinhua, Zhejiang, China
Klinicki bolnicki centar Sestre milosrdnice /ID# 157721
🇭🇷Zagreb, Grad Zagreb, Croatia
Universitaetsklinikum Erlangen /ID# 159315
🇩🇪Erlangen, Bayern, Germany
Universitaetsklinikum Frankfurt /ID# 212978
🇩🇪Frankfurt am Main, Hessen, Germany
Universitaetsklinikum Muenster /ID# 159316
🇩🇪Muenster, Nordrhein-Westfalen, Germany
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159322
🇩🇪Berlin, Germany
University of Catanzaro /ID# 212012
🇮🇹Catanzaro, Calabria, Italy
EUGASTRO GmbH /ID# 212076
🇩🇪Leipzig, Germany
Duplicate_Gastro-Praxis Wiesbaden /ID# 159318
🇩🇪Wiesbaden, Germany
A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 155635
🇮🇹Bologna, Italy
Nagoya University Hospital /ID# 160150
🇯🇵Nagoyashi, Aichi, Japan
Fukuoka University Hospital /ID# 217792
🇯🇵Fukuoka-shi, Fukuoka, Japan
Nishinomiya Munic Central Hospital /ID# 210104
🇯🇵Nishinomiya-shi, Hyogo, Japan
Unidad de Atencion Medica e Investigacion en Salud /ID# 163624
🇲🇽Merida, Yucatan, Mexico
Elisabeth Tweesteden Ziekenhuis /ID# 163631
🇳🇱Tilburg, Netherlands
Christchurch Hospital /ID# 163074
🇳🇿Christchurch, Canterbury, New Zealand
Universitatsklinikum Mannheim /ID# 162020
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Kurume University Hospital /ID# 160138
🇯🇵Kurume-shi, Fukuoka, Japan
Hiroshima University Hospital /ID# 160139
🇯🇵Hiroshima-shi, Hiroshima, Japan
NHO Shizuoka Medical Center /ID# 163029
🇯🇵Sunto-gun, Shizuoka, Japan
Tokyo Medical And Dental University, Medical Hospital /ID# 160157
🇯🇵Bunkyo-ku, Tokyo, Japan
Kangbuk Samsung Hospital /ID# 158676
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Pauls Stradins Clinical University Hospital /ID# 159614
🇱🇻Riga, Latvia
Queen Elizabeth Hospital /ID# 160654
🇲🇾Division Pantai Barat Utara, Sabah, Malaysia
Planetmed Sp. z o.o. /ID# 202798
🇵🇱Wroclaw, Dolnoslaskie, Poland
Duplicate_SOLUMED Sp. z o.o., Sp.k. /ID# 160793
🇵🇱Poznan, Poland
Hospital Garcia de Orta, EPE /ID# 160747
🇵🇹Almada, Portugal
Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167749
🇵🇹Lisboa, Portugal
Samsung Medical Center /ID# 158674
🇰🇷Seoul, Korea, Republic of
Dunedin Hospital /ID# 167989
🇳🇿Dunedin, Otago, New Zealand
1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 209985
🇵🇱Lublin, Lubelskie, Poland
Wojewodzki Szpital Specjalistyczny /ID# 212402
🇵🇱Olsztyn, Warminsko-mazurskie, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212602
🇵🇱Wroclaw, Poland
Kingsbury Hospital /ID# 163116
🇿🇦Cape Town, Western Cape, South Africa
Duplicate_Centrul Medical Tuculanu SRL /ID# 166295
🇷🇴Timisoara, Romania
Kuzbass Regional Clinical Hospital /ID# 161310
🇷🇺Kemerovo, Kemerovskaya Oblast, Russian Federation
Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207440
🇷🇺Perm, Permskiy Kray, Russian Federation
Duplicate_St. Petersburg State Pediatric Medical University /ID# 211977
🇷🇺Saint Petersburg, Sankt-Peterburg, Russian Federation
Regional Clinical Hospital #1 /ID# 163453
🇷🇺Tyumen, Tyumenskaya Oblast, Russian Federation
University Clinical Center Kragujevac /ID# 156975
🇷🇸Kragujevac, Sumadijski Okrug, Serbia
Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 165649
🇺🇦Kharkiv, Ukraine
MNPE Vinnytsia Regional Clinical Hospital n.a. M.I. Pyrohov /ID# 216265
🇺🇦Vinnytsia, Ukraine
Scientific Research Institute of Invalid Rehabilitation /ID# 211516
🇺🇦Vinnytsia, Vinnytska Oblast, Ukraine
Institutul Clinic Fundeni /ID# 163264
🇷🇴Sector 2, Bucuresti, Romania
Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 156949
🇷🇺Stavropol, Stavropol Skiy Kray, Russian Federation
State Scientific Ctr Coloproct /ID# 204809
🇷🇺Moscow, Russian Federation
Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160695
🇵🇹Porto, Portugal
Institutul Clinic Fundeni /ID# 163046
🇷🇴Sector 2, Bucuresti, Romania
Tver Regional Clinical Hospital /ID# 205925
🇷🇺Tver, Tverskaya Oblast, Russian Federation
Alliance Biomedical Ural Group /ID# 156950
🇷🇺Izhevsk, Udmurtskaya Respublika, Russian Federation
Military Medical Academy /ID# 156979
🇷🇸Belgrade, Beograd, Serbia
Communal Enterprise Volyn Regional Clinical hospital of the Volyn Regional Coun /ID# 206788
🇺🇦Lutsk, Ukraine
Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207937
🇬🇧Chertsey, Surrey, United Kingdom
National University Hospital /ID# 160658
🇸🇬Singapore, Singapore
Singapore General Hospital /ID# 160657
🇸🇬Singapore, Singapore
International Institute of Clinical Research LLC /ID# 211997
🇺🇦Kyiv, Ukraine
Universitätsspital Zürich /ID# 163532
🇨🇭Zürich, Zuerich, Switzerland
Kyiv Railway Clinical Hosp No.2 /ID# 217330
🇺🇦Kyiv, Ukraine
Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 165650
🇺🇦Lviv, Ukraine
Clinresco Centers /ID# 163864
🇿🇦Johannesburg, Gauteng, South Africa
Mayo Clinic - Rochester /ID# 163085
🇺🇸Rochester, Minnesota, United States
University of Nebraska Medical Center /ID# 210057
🇺🇸Omaha, Nebraska, United States
Hightower Clinical /ID# 211938
🇺🇸Oklahoma City, Oklahoma, United States
Digestive Disease Specialists /ID# 170774
🇺🇸Oklahoma City, Oklahoma, United States
Northwest Gastroenterology Clinic /ID# 158288
🇺🇸Portland, Oregon, United States
Beaumont Hospital /ID# 157515
🇮🇪Beaumont, Dublin, Ireland
HonorHealth Research Institute - Shea /ID# 161783
🇺🇸Scottsdale, Arizona, United States
Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211883
🇺🇸Tempe, Arizona, United States
University of Arizona /ID# 158469
🇺🇸Tucson, Arizona, United States
Phoenix VA Health Care System /ID# 162267
🇺🇸Phoenix, Arizona, United States
Atria Clinical Research /ID# 164740
🇺🇸Little Rock, Arkansas, United States
United Medical Doctors - Murrieta /ID# 158424
🇺🇸Murrieta, California, United States
Newport Huntington Medica /ID# 213033
🇺🇸Huntington Beach, California, United States
United Medical Doctors /ID# 207040
🇺🇸Los Alamitos, California, United States
Southern CA Research Ctr., Inc /ID# 167875
🇺🇸Riverside, California, United States
Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162656
🇺🇸Los Angeles, California, United States
Cedars-Sinai Medical Center-West Hollywood /ID# 163842
🇺🇸West Hollywood, California, United States
Western Connecticut Medical Group /ID# 165849
🇺🇸Danbury, Connecticut, United States
Clinical Research of West Florida, Inc /ID# 204859
🇺🇸Clearwater, Florida, United States
Seffner Premier Health Care, PA /ID# 162265
🇺🇸Brandon, Florida, United States
South Lake Pain Institute, Inc /ID# 162825
🇺🇸Clermont, Florida, United States
Clinical Research of West Florida, Inc /ID# 207450
🇺🇸Clearwater, Florida, United States
Nature Coast Clinical Research - Inverness /ID# 159414
🇺🇸Inverness, Florida, United States
Alliance Medical Research /ID# 163840
🇺🇸Lighthouse Point, Florida, United States
Cfagi Llc /Id# 201571
🇺🇸Maitland, Florida, United States
Gastroenterology Group Naples /ID# 165206
🇺🇸Naples, Florida, United States
ITB Research /ID# 161334
🇺🇸Miami, Florida, United States
South Florida Research Ph I-IV, Inc. /ID# 161836
🇺🇸Miami, Florida, United States
Advanced Research Institute, Inc /ID# 161959
🇺🇸New Port Richey, Florida, United States
IMIC Inc. Medical Research /ID# 154943
🇺🇸Palmetto Bay, Florida, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 154857
🇺🇸Macon, Georgia, United States
Northwestern University Division of GI/Hepatology /ID# 158283
🇺🇸Chicago, Illinois, United States
Houma Digestive Health Special /ID# 158286
🇺🇸Houma, Louisiana, United States
Gastroenterology Associates LLC - Jefferson Hwy /ID# 161956
🇺🇸Baton Rouge, Louisiana, United States
University of Kentucky Chandler Medical Center /ID# 157137
🇺🇸Lexington, Kentucky, United States
MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 154839
🇺🇸Chevy Chase, Maryland, United States
Louisana Research Center, LLC /ID# 162236
🇺🇸Shreveport, Louisiana, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161328
🇺🇸Wyoming, Michigan, United States
Gastro Center of Maryland /ID# 165004
🇺🇸Columbia, Maryland, United States
St. Louis University /ID# 161902
🇺🇸Saint Louis, Missouri, United States
Southern Therapy and Advanced Research (STAR) LLC /ID# 162388
🇺🇸Jackson, Mississippi, United States
Center for Digestive Health /ID# 154690
🇺🇸Troy, Michigan, United States
NY Scientific /ID# 158418
🇺🇸Brooklyn, New York, United States
Intercity Advanced Gastroentertology Center /ID# 213399
🇺🇸Fresh Meadows, New York, United States
Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 212036
🇺🇸Burnt Hills, New York, United States
North Shore University Hospital /ID# 168736
🇺🇸New Hyde Park, New York, United States
Digestive Disease Care /ID# 209619
🇺🇸New Hyde Park, New York, United States
Lenox Hill Hospital /ID# 168465
🇺🇸New York, New York, United States
Columbia Univ Medical Center /ID# 161911
🇺🇸New York, New York, United States
NYU Langone Medical Center /ID# 160171
🇺🇸New York, New York, United States
DiGiovanna Institute for Medical Education & Research /ID# 171118
🇺🇸North Massapequa, New York, United States
Vidant Multispecialty Clinic - Kinston /ID# 161111
🇺🇸Kinston, North Carolina, United States
Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154880
🇺🇸Raleigh, North Carolina, United States
Tri-State Endoscopy /ID# 154933
🇺🇸Cincinnati, Ohio, United States
The Ohio State University /ID# 164709
🇺🇸Columbus, Ohio, United States
Hometown Urgent Care and Resea /ID# 170453
🇺🇸Dayton, Ohio, United States
Optimed Research, Ltd. /ID# 167901
🇺🇸Columbus, Ohio, United States
Great Lakes Medical Research, LLC /ID# 201732
🇺🇸Mentor, Ohio, United States
Digestive Disease Associates, LTD /ID# 208847
🇺🇸Wyomissing, Pennsylvania, United States
Gastro One /ID# 154742
🇺🇸Germantown, Tennessee, United States
Rapid City Medical Center - GI Research /ID# 163841
🇺🇸Rapid City, South Dakota, United States
East Tennessee Research Institute /ID# 168737
🇺🇸Johnson City, Tennessee, United States
Inquest Clinical Research /ID# 165695
🇺🇸Baytown, Texas, United States
TX Clinical Research Institute /ID# 159410
🇺🇸Arlington, Texas, United States
Duplicate_Clinical Neuroscience Solutions /ID# 164181
🇺🇸Memphis, Tennessee, United States
Texas Digestive Disease Consultants /ID# 209596
🇺🇸Cedar Park, Texas, United States
Texas Digestive Disease Consultants /ID# 209785
🇺🇸Cedar Park, Texas, United States
Vilo Research Group Inc /ID# 206130
🇺🇸Houston, Texas, United States
DHAT Research Institute /ID# 158217
🇺🇸Garland, Texas, United States
Precision Research Institute, LLC /ID# 200503
🇺🇸Houston, Texas, United States
Gastro Health & Nutrition - Victoria /ID# 164296
🇺🇸Victoria, Texas, United States
Tyler Research Institute, LLC /ID# 166796
🇺🇸Tyler, Texas, United States
Advanced Research Institute /ID# 154914
🇺🇸Ogden, Utah, United States
Washington Gastroenterology Associates /ID# 162120
🇺🇸Bellevue, Washington, United States
Hospital Privado Univesitario /ID# 161988
🇦🇷Cordoba, Argentina
Griffith University /ID# 212627
🇦🇺Southport, Queensland, Australia
Emeritus Research /ID# 213511
🇦🇺Camberwell, Victoria, Australia
Footscray Hospital /ID# 211361
🇦🇺Footscray, Victoria, Australia
Lyell McEwin Hospital /ID# 211363
🇦🇺Elizabeth Vale, South Australia, Australia
Universitaetsklinikum St. Poelten /ID# 166425
🇦🇹Sankt Poelten, Niederoesterreich, Austria
Medizinische Universitaet Graz /ID# 158137
🇦🇹Graz, Steiermark, Austria
Krankenhaus der Barmherzigen Brueder Wien /ID# 212059
🇦🇹Vienna, Wien, Austria
ULB Hospital Erasme /ID# 157397
🇧🇪Brussels, Bruxelles-Capitale, Belgium
UCL Saint-Luc /ID# 157395
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
UZ Gent /ID# 157394
🇧🇪Gent, Oost-Vlaanderen, Belgium
Upeclin Fmb - Unesp /Id# 157688
🇧🇷Botucatu, Sao Paulo, Brazil
Hospital Nossa Senhora das Graças /ID# 157646
🇧🇷Curitiba, Parana, Brazil
Kaiser Clinica e Hospital Dia /ID# 157656
🇧🇷Sao Jose Do Rio Preto, Sao Paulo, Brazil
Faculdade de Medicina do ABC /ID# 159672
🇧🇷Santo André, Sao Paulo, Brazil
UMHAT Dr Georgi Stranski EAD /ID# 203977
🇧🇬Pleven, Bulgaria
University Multiprofile Hospit /ID# 158644
🇧🇬Plovdiv, Bulgaria
Duplicate_Tokuda Hospital Sofia /ID# 158645
🇧🇬Sofia, Bulgaria
Second Multiprofile Hospital f /ID# 158646
🇧🇬Sofia, Bulgaria
University of Calgary - Heritage Medical Research Clinic /ID# 157152
🇨🇦Calgary, Alberta, Canada
Covenant Health /ID# 161617
🇨🇦Edmonton, Alberta, Canada
Percuro Clinical Research, Ltd /ID# 161616
🇨🇦Victoria, British Columbia, Canada
Scott Shulman Medicine Professional Corporation /ID# 165903
🇨🇦North Bay, Ontario, Canada
Toronto Digestive Disease Asso /ID# 157157
🇨🇦Vaughan, Ontario, Canada
CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159054
🇨🇦Montreal, Quebec, Canada
CHUM - Centre hospitalier de l'Universite de Montréal /ID# 167066
🇨🇦Montreal, Quebec, Canada
Complejo Asistencial Dr. Sotero del Rio /ID# 169382
🇨🇱Santiago, Region Metropolitana De Santiago, Chile
Hospital Guillermo Grant Benavente de Concepción /ID# 210759
🇨🇱Concepción, Chile
ResTrial s.r.o. /ID# 211075
🇨🇿Praha, Czechia
Guangdong Provincial People's Hospital /ID# 212948
🇨🇳Guangzhou, Guangdong, China
The Second Hospital of Hebei Medical University /ID# 212740
🇨🇳Shijiazhuang, Hebei, China
The Sixth Affiliated Hosp Sun /ID# 210785
🇨🇳Guangzhou, Guangdong, China
The First Affiliated Hospital of Nanchang University /ID# 211034
🇨🇳Nanchang, Jiangxi, China
NH Hospital a.s. /ID# 211076
🇨🇿Praha, Czechia
Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210841
🇨🇳Shanghai, Shanghai, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210624
🇨🇳Hangzhou, Zhejiang, China
The second Affiliated hospital of Zhejiang University school of Medicine /ID# 210725
🇨🇳Hangzhou, Zhejiang, China
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210707
🇨🇳Shanghai, Shanghai, China
The Second Hospital Central South University /ID# 211696
🇨🇳Changsha, China
West China Hospital, Sichuan University /ID# 210889
🇨🇳Chengdu, China
Instituto de Coloproctologia /ID# 158741
🇨🇴Medellin, Antioquia, Colombia
Duplicate_Klinicka bolnica Dubrava Zagreb /ID# 157565
🇭🇷Zagreb, Grad Zagreb, Croatia
UHC Osijek /ID# 157564
🇭🇷Osijek, Osjecko-baranjska Zupanija, Croatia
Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165463
🇨🇿Prague 4, Praha 4, Czechia
Klinicki bolnicki centar Split /ID# 157567
🇭🇷Split, Splitsko-dalmatinska Zupanija, Croatia
Hepato-Gastroenterologie HK, s.r.o. /ID# 163134
🇨🇿Hradec Kralove, Czechia
CTCenter MaVe s.r.o. /ID# 163149
🇨🇿Olomouc, Czechia
Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211305
🇨🇿Praha, Czechia
Nemocnice Pardubickeho kraje, a.s. /ID# 163182
🇨🇿Pardubice, Czechia
Thomayerova nemocnice /ID# 162940
🇨🇿Praha, Czechia
Axon Clinical, s.r.o. /ID# 163176
🇨🇿Praha, Czechia
West Tallinn Central Hospital /ID# 157077
🇪🇪Tallinn, Estonia
Praxis fuer Gastroenterologie /ID# 166145
🇩🇪Heidelberg, Baden-Wuerttemberg, Germany
Universitaetsklinikum Freiburg /ID# 162019
🇩🇪Freiburg, Baden-Wuerttemberg, Germany
Universitaetsklinikum Ulm /ID# 164986
🇩🇪Ulm, Baden-Wuerttemberg, Germany
Evangelisches Krankenhaus Kalk /ID# 212725
🇩🇪Cologne, Nordrhein-Westfalen, Germany
Universitaetsklinikum Koeln /ID# 164985
🇩🇪Köln, Nordrhein-Westfalen, Germany
Universitaetsklinikum Jena /ID# 159323
🇩🇪Jena, Thueringen, Germany
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212219
🇩🇪Berlin, Germany
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212893
🇩🇪Berlin, Germany
Krankenhaus Waldfriede /ID# 212728
🇩🇪Berlin-Zehlendorf, Germany
DRK Kliniken Berlin Westend /ID# 166146
🇩🇪Berlin, Germany
Stadtisches Klinikum Braunschweig /ID# 163666
🇩🇪Braunschweig, Germany
Medizinisches Versorgunszentrum Dachau /ID# 211557
🇩🇪Dachau, Germany
Asklepios Westklinikum Hamburg /ID# 159319
🇩🇪Hamburg, Germany
Agaplesion Markus Krankenhaus /ID# 159317
🇩🇪Frankfurt am Main, Germany
Klinikum Lueneburg /ID# 163664
🇩🇪Lueneburg, Germany
Medizinische Hochschule Hannover /ID# 162021
🇩🇪Hannover, Germany
Gastroenterologische Gemeinschaftspraxis Minden /ID# 162018
🇩🇪Minden, Germany
Universitaetsklinikum Magdeburg /ID# 211847
🇩🇪Magdeburg, Germany
University General Hospital of Heraklion PA.G.N.I /ID# 157427
🇬🇷Heraklion, Kriti, Greece
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 171077
🇬🇷Athens, Attiki, Greece
Tzaneio general hospital of Piraeus /ID# 206445
🇬🇷Piraeus, Attiki, Greece
General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 157429
🇬🇷Pireaus, Greece
University General Hospital of Ioannina /ID# 157425
🇬🇷Ioannina, Greece
Queen Mary Hospital /ID# 163902
🇭🇰Hong Kong, Hong Kong
Theageneio Anticancer Hospital /ID# 163921
🇬🇷Thessaloniki, Greece
Soroka University Medical Center /ID# 157798
🇮🇱Be'er Sheva, HaDarom, Israel
Sheba Medical Center /ID# 157797
🇮🇱Ramat Gan, Tel-Aviv, Israel
Sheba Medical Center /ID# 171074
🇮🇱Ramat Gan, Tel-Aviv, Israel
Shaare Zedek Medical Center /ID# 163540
🇮🇱Jerusalem, Israel
The Edith Wolfson Medical Center /ID# 217329
🇮🇱Holon, Israel
Tel Aviv Sourasky Medical Center /ID# 157796
🇮🇱Tel Aviv-Yafo, Tel-Aviv, Israel
Duplicate_Rambam Medical Center /ID# 171072
🇮🇱Haifa, Israel
Shaare Zedek Medical Center /ID# 171073
🇮🇱Jerusalem, Israel
Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162427
🇮🇹Torrette, Ancona, Italy
Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212019
🇮🇹Modena, Emilia-Romagna, Italy
Policlinico Universitario Campus Bio-Medico /ID# 162429
🇮🇹Rome, Lazio, Italy
Istituto Clinico Humanitas /ID# 155634
🇮🇹Rozzano, Milano, Italy
Azienda Ospedaliera San Camillo Forlanini /ID# 155636
🇮🇹Rome, Lazio, Italy
Fondazione PTV Policlinico Tor Vergata /ID# 158021
🇮🇹Rome, Roma, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166911
🇮🇹Rome, Lazio, Italy
Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155632
🇮🇹Rome, Roma, Italy
Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 168051
🇮🇹Florence, Toscana, Italy
A.O. Per L'Emergenza Cannizzaro /ID# 161306
🇮🇹Catania, Italy
Ospedale Policlinico San Martino /ID# 162430
🇮🇹Genova, Italy
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 155633
🇮🇹Milan, Italy
ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155631
🇮🇹Milano, Italy
Duplicate_Fondazione IRCCS Policlinico San Matteo /ID# 212029
🇮🇹Pavia, Italy
Daido Clinic /ID# 211477
🇯🇵Nagoya-shi, Aichi, Japan
Fujita Health University Hospital /ID# 163214
🇯🇵Toyoake-shi, Aichi, Japan
The Jikei University Kashiwa Hospital /ID# 200007
🇯🇵Kashiwa-shi, Chiba, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160158
🇯🇵Sapporo-shi, Hokkaido, Japan
Sapporo Tokushukai Hospital /ID# 213493
🇯🇵Sapporo-shi, Hokkaido, Japan
Hyogo College of Medicine College Hospital /Id# 160164
🇯🇵Nishinomiya-shi, Hyogo, Japan
National Hospital Organization Mito Medical Center /ID# 160154
🇯🇵Higashi Ibaraki-gun, Ibaraki, Japan
Kitasato University Hospital /ID# 171071
🇯🇵Sagamihara-shi, Kanagawa, Japan
Gokeikai Ofuna Chuo Hospital /ID# 171070
🇯🇵Kamakura-shi, Kanagawa, Japan
Mie University Hospital /ID# 203639
🇯🇵Tsu-shi, Mie, Japan
Yokohama City University Medical Center /ID# 163906
🇯🇵Yokohama shi, Kanagawa, Japan
Yokkaichi Hazu Medical Center /ID# 163741
🇯🇵Yokkaichi-shi, Mie, Japan
Osaka City University Hospital /ID# 160146
🇯🇵Osaka-shi, Osaka, Japan
Tohoku University Hospital /ID# 162843
🇯🇵Sendai-shi, Miyagi, Japan
Duplicate_Tohoku Rosai Hospital /ID# 163189
🇯🇵Sendai-shi, Miyagi, Japan
Saitama Medical Center /ID# 160155
🇯🇵Kawagoe-shi, Saitama, Japan
Tokitokai Tokito clinic /ID# 160145
🇯🇵Saitama-shi, Saitama, Japan
Shiga University of Medical Science Hospital /ID# 164022
🇯🇵Otsu-shi, Shiga, Japan
Hamamatsu University Hospital /ID# 205689
🇯🇵Hamamatsu-shi, Shizuoka, Japan
Duplicate_Tokai University Hachioji Hospital /ID# 160160
🇯🇵Hachioji-shi, Tokyo, Japan
Wakayama Medical University Hospital /ID# 200183
🇯🇵Wakayama-shi, Wakayama, Japan
Yamanashi Prefectural Central Hospital /ID# 160156
🇯🇵Kofu-shi, Yamanashi, Japan
Duplicate_CHA bundang medical center CHA University /ID# 158672
🇰🇷Seongnam-si, Gyeonggido, Korea, Republic of
Duplicate_The Catholic University of Korea, ST. Vincent's Hospital /ID# 158681
🇰🇷Suwon, Gyeonggido, Korea, Republic of
Dong-A University Hospital /ID# 158675
🇰🇷Busan, Korea, Republic of
Pusan National University Hospital /ID# 158677
🇰🇷Busan, Korea, Republic of
Yeungnam University Medical Center /ID# 158680
🇰🇷Daegu, Korea, Republic of
Digestive Disease Center Gastro /ID# 163105
🇱🇻Riga, Latvia
Duplicate_Vilnius University Hospital /ID# 162507
🇱🇹Vilnius, Lithuania
Universiti Sains Malaysia /ID# 160656
🇲🇾Kelantan, Malaysia
Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 167648
🇲🇽Zapopan, Jalisco, Mexico
JM Research SC /ID# 161733
🇲🇽Cuernavaca, Morelos, Mexico
Health Pharma Professional Research S.A de C.V /ID# 161734
🇲🇽Del. Benito Juárez, Mexico
Wellington Regional Hospital /ID# 167987
🇳🇿Newtown Wellington, Wellington, New Zealand
Akershus universitetssykehus /ID# 169378
🇳🇴Nordbyhagen, Akershus, Norway
Vestre viken - Baerum Sykehus /ID# 157886
🇳🇴Gjettum, Norway
Helse More og Romsdal HF, Alesund sjukehus /ID# 212811
🇳🇴Ålesund, Norway
Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212297
🇵🇱Lodz, Lodzkie, Poland
Centrum Zdrowia MDM /ID# 160794
🇵🇱Warszawa, Mazowieckie, Poland
Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 160797
🇵🇱Warszawa, Mazowieckie, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie /ID# 209981
🇵🇱Lublin, Lubelskie, Poland
Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213579
🇵🇱Warszawa, Mazowieckie, Poland
Centrum Medyczne LukaMed Joanna Luka-Wendrowska /ID# 212081
🇵🇱Chojnice, Pomorskie, Poland
H-T. Centrum Medyczne - Endoterapia /ID# 212459
🇵🇱Tychy, Slaskie, Poland
Duplicate_Niepubliczny Zakład Opieki Zdrowotnej VIVAMED Jadwiga Miecz /ID# 205160
🇵🇱Warsaw, Poland
Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167750
🇵🇹Portimão, Faro, Portugal
Centro Hospitalar de Entre Douro e Vouga /ID# 160674
🇵🇹Santa Maria Da Feira, Porto, Portugal
Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 160675
🇵🇹Lisboa, Portugal
Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 160694
🇵🇹Lisboa, Portugal
Duplicate_Ulyanovsk State clinical hospi /ID# 156946
🇷🇺Ulyanovsk, Russian Federation
City Clinical Hospital No. 31 /ID# 208866
🇷🇺St. Petersburg, Russian Federation
Clin Hosp Ctr Bezanijska Kosa /ID# 156976
🇷🇸Belgrade, Beograd, Serbia
University Clinical Center Serbia /ID# 156973
🇷🇸Belgrade, Beograd, Serbia
Clinical Center Vojvodina /ID# 156972
🇷🇸Novi Sad, Vojvodina, Serbia
University Children's Hospital 'Tirsova' /ID# 211481
🇷🇸Belgrade, Serbia
General Hospital Leskovac /ID# 209574
🇷🇸Leskovac, Serbia
Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212797
🇷🇸Belgrade, Serbia
KL Ling Gastroenterology and Liver Clinic /ID# 205737
🇸🇬Singapore, Singapore
Univerzitna nemocnica Martin /ID# 163200
🇸🇰Martin, Slovakia
Wits Clinical Research Site /ID# 158115
🇿🇦Johannesburg, Gauteng, South Africa
Spoke Research Inc /ID# 158117
🇿🇦CAPE TOWN Milnerton, Western Cape, South Africa
Private Practice Dr MN Rajabally /ID# 163115
🇿🇦Cape Town, Western Cape, South Africa
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159230
🇪🇸Sabadell, Barcelona, Spain
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157527
🇪🇸Ferrol, A Coruna, Spain
Hospital Clinic de Barcelona /ID# 157526
🇪🇸Barcelona, Spain
Hospital Universitario Virgen Macarena /ID# 160819
🇪🇸Sevilla, Spain
Hospital Universitario y Politecnico La Fe /ID# 157530
🇪🇸Valencia, Spain
Hospital Clinico Universitario Lozano Blesa /ID# 212523
🇪🇸Zaragoza, Spain
Hospital Universitario Miguel Servet /ID# 157531
🇪🇸Zaragoza, Spain
Ersta diakoni /ID# 157878
🇸🇪Stockholm, Stockholms Lan, Sweden
Sahlgrenska University Hospital /ID# 157879
🇸🇪Gothenburg, Vastra Gotalands Lan, Sweden
Danderyd Hospital /ID# 202136
🇸🇪Stockholm, Stockholms Lan, Sweden
Duplicate_SU Molndal. /ID# 157880
🇸🇪Molndal, Sweden
Duplicate_Universitaetsspital Basel /ID# 164555
🇨🇭Basel, Switzerland
Duplicate_Karolinska Univ Sjukhuset /ID# 209966
🇸🇪Solna, Sweden
Communal Noncommercial Institution Consultative and Diagnostic Center of Desnian /ID# 165651
🇺🇦Kyiv, Ukraine
Duplicate_Transcarpathian Regional Clin. /ID# 168419
🇺🇦Uzhhorod, Ukraine
Royal Devon and Exeter NHS Trust Hospital /ID# 157517
🇬🇧Exeter, Devon, United Kingdom
Guy's and St Thomas' NHS Foundation Trust /ID# 157519
🇬🇧London, London, City Of, United Kingdom
Kyiv Municipal Clinical Hospital #18 /ID# 162521
🇺🇦Київ, Ukraine
Barts Health NHS Trust /ID# 163710
🇬🇧London, London, City Of, United Kingdom
Cambridge University Hospitals NHS Foundation Trust /ID# 158031
🇬🇧Cambridge, United Kingdom
NHS Lothian /ID# 207447
🇬🇧Edinburgh, United Kingdom
Leeds Teaching Hospitals NHS Trust /ID# 157523
🇬🇧Leeds, United Kingdom
Calderdale and Huddersfield NHS Foundation Trust /ID# 209569
🇬🇧Huddersfield, United Kingdom
Hull University Teaching Hospitals NHS Trust /ID# 158757
🇬🇧Hull, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163709
🇬🇧Newcastle Upon Tyne, United Kingdom
Duplicate_King's College Hospital NHS Foundation Trusts /ID# 158756
🇬🇧London, United Kingdom
Oxford University Hospitals NHS Foundation Trust /ID# 158033
🇬🇧Oxford, United Kingdom
Duplicate_Northern Care Alliance NHS Group /ID# 207764
🇬🇧Salford, United Kingdom
NorthShore University HealthSystem /ID# 158287
🇺🇸Evanston, Illinois, United States
Adult Gastroenterology Associates - Gen 1 Research /ID# 206125
🇺🇸Tulsa, Oklahoma, United States
PennState Milton S.Hershey Med /ID# 154883
🇺🇸Hershey, Pennsylvania, United States
Endoscopic Research, Inc. /ID# 205901
🇺🇸Orlando, Florida, United States
Omega Research Maitland, LLC /ID# 171081
🇺🇸Orlando, Florida, United States
Clinical Research Trials of Florida, Inc. /ID# 201014
🇺🇸Tampa, Florida, United States
University of Louisville /ID# 210521
🇺🇸Louisville, Kentucky, United States
Univ NC Chapel Hill /ID# 154840
🇺🇸Chapel Hill, North Carolina, United States
McGuire DV AMC /ID# 159990
🇺🇸Richmond, Virginia, United States
Delricht Research /ID# 206542
🇺🇸New Orleans, Louisiana, United States
University of Michigan Health Systems /ID# 157144
🇺🇸Ann Arbor, Michigan, United States
Medical University of South Carolina /ID# 212579
🇺🇸Charleston, South Carolina, United States
Nola Research Works, LLC /ID# 161330
🇺🇸New Orleans, Louisiana, United States
Tokyo Women's Medical University Hospital /ID# 205973
🇯🇵Shinjuku-ku, Tokyo, Japan
Kyorin University Hospital /ID# 160149
🇯🇵Mitaka-shi, Tokyo, Japan
Medicor Research Inc /ID# 157149
🇨🇦Sudbury, Ontario, Canada
Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211972
🇩🇪Berlin, Germany
Hospital Pablo Tobon Uribe /ID# 158735
🇨🇴Medellín, Antioquia, Colombia
Tuen Mun Hospital /ID# 163901
🇭🇰Tuen Mun, Hong Kong