Assessment of a novel strategy to attenuate muscle mass loss during 2 weeks of bed rest
Completed
- Conditions
- Disuse, Immobilization, Injury
- Registration Number
- NL-OMON22281
- Lead Sponsor
- Maastricht University
- Brief Summary
n/a
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
•Healthy males
•Age between 18 and 35 y
Exclusion Criteria
•Smoking
•Type 2 Diabetes Mellitus
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the amount of muscle mass that is lost following 2 weeks of bed rest and whether BFR can be applied to effectively preserve muscle mass and strength during bed rest.
- Secondary Outcome Measures
Name Time Method To assess differences in muscle fiber cross-sectional area (CSA), satellite cell content/activation, muscle fiber vascularization, muscle protein synthesis rates between both legs (BFR vs control), muscle strength, whole-body fat mass, adipose tissue gene expression and oral glucose tolerance before and after 2 weeks of bed rest.