Protocol for Muscle Attenuation Cut-offs in Cirrhosis

Completed

• Conditions: Cirrhosis; Myosteatosis; Sarcopenia; Sarcopenia in Liver Cirrhosis; Portal Hypertension Related to Cirrhosis; Malnutrition

• Registration Number: NCT06593015
• Lead Sponsor: University of Roma La Sapienza

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-9-4
• Last Update Posted: 23 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1296

Inclusion Criteria

Inclusion Criteria:<br><br>Retrospective cohort:<br><br> - Clinical, radiological and/or histological diagnosis of cirrhosis<br><br> - Abdominal CT-scan obtained as part of the LT evaluation<br><br>Prospective cohort:<br><br> - Clinical, radiological and/or histological diagnosis of cirrhosis<br><br> - Age 40-75 years<br><br> - Abdominal CT-scan<br><br>Exclusion Criteria:<br><br>Retrospective cohort:<br><br> - Multi-organ transplantation<br><br> - Re-transplantation<br><br>Prospective cohort:<br><br> - Patient on LT waiting lists<br><br> - Hepatocellular carcinoma (HCC)<br><br> - History of LT<br><br> - Concomitant neuromuscular disease<br><br> - Current malignancy other than non-melanocytic skin cancer<br><br> - History of serious extrahepatic disease<br><br> - HIV infection.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Definition of new L3/L3-L4 muscle attenuation cut-offs to define myosteatosis in relation to risk of death in patients with cirrhosis

Secondary Outcome Measures

Name	Time	Method
Association of newly defined myosteatosis with risk of clinical events in patients with cirrhosis