Reproductive and Obstetric Outcomes in TESE-ICSI Cycles: a Comparison Between Obstructive and Non-obstructive Azoospermia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 520
- 主要终点
- Abortion rate
研究概览
简要总结
A comparison of reproductive and obstetrical outcomes is retrospectively performed among couples that underwent ICSI-TESE cycles for obstructive and non obstructive azoospermia between January 2001 and December 2019.
详细描述
Azoospermia affects almost 20% of all infertile males and It can be divided into obstructive azoospermia (OA) and nonobstructive azoospermia (NOA). Assisted fertilization with testicular sperm extraction (TESE) and intracytoplasmatic sperm injection (ICSI) has been successfully applied for its treatment.
Review of the literature shows that there is a lack of consensus about reproductive outcomes between men with OA and NOA. No study has ever investigated differences in obstetrical outcomes between these two groups before.
The objective of this study is to retrospectively determine differences in reproductive and obstetrical outcomes among couples that underwent ICSI-TESE cycles for obstructive and non obstructive azoospermia.
The primary outcomes that will be investigated include:
- Reproductive outcomes: pregnancy rate, live birth rate (LBR) and abortion rate.
- Obstetrical outcomes: twinning rate, gestational age, prematurity rate, birth weight, cesarean section rate and the rate of the main obstetrical complication, such as pre-eclampsia, gestational hypertension, intrauterine growth restriction (IUGR).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Sperm donation
- •Use of ejaculated sperm
- •Couples who underwent pre-implantation genetic testing
结局指标
主要结局
Abortion rate
时间窗: 20 years (2001-2019)
Proportion of clinical pregnancies who failed to continue beyond 22 weeks of gestation
Live birth rate (LBR)
时间窗: 20 years (2001-2019)
Rate of delivery of a living baby after at least 22 weeks of gestation
Pregnancy rate
时间窗: 20 years (2001-2019)
Total number of pregnancies including live births, abortions and fetal death
Gestational age
时间窗: 20 years (2001-2019)
Mean gestational age of the pregnancies considered (written with both weeks and days)
Maternal complications rate
时间窗: 20 years (2001-2019)
Incidence of the obstetric complications, such as pre-eclampsia, gestational hypertension, placenta previa and placental abruption, intrauterine growth restriction.
Twinning rate
时间窗: 20 years (2001-2019)
Rate of twin deliveries out of the total number of deliveries
Cesarean section rate
时间窗: 20 years (2001-2019)
Rate of cesarean section deliveries out of the total number of deliveries
Prematurity rate
时间窗: 20 years (2001-2019)
Rate of pregnancies lasted less than 37 weeks and 0 days
Birth weight
时间窗: 20 years (2001-2019)
Mean birth weight of the neonates written in grams.
次要结局
未报告次要终点