Enhanced Recovery After Surgery Promotes the Rehabilitation of Patients With Acute Gastrointestinal Perforation in Perioperative Period

Not Applicable

Completed

• Conditions: Acute Gastrointestinal Perforation; Enhanced Recovery After Surgery

• Registration Number: NCT07008313
• Lead Sponsor: Hebei Medical University

Brief Summary

The enhanced recovery after surgery(ERAS) has been gradually extended from its initial colorectal surgery to almost all surgical fields. However, there are few reports about the application value of ERAS in emergency surgery. The goal of this clinical trial is to evaluate the value of ERAS in the perioperative period of acute gastrointestinal perforation. All the patients will be treated by emergency operation. The changes of CRP, PA, PCT in Plasma 1 hour before operation and 1,3,7 days after operation, the operation time, the amount of bleeding during operation, the recovery time of intestinal function and the time of the first meal after operation,the incidence of postoperative complications, the degree of postoperative pain, the time of first out-of-bed activity, fatigue and mental status, quality of life, the length and the cost of hospital stay will be monitored and recorded.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-01
• Primary Completion: 2023-01-01
• Study Completion: 2023-01-31
• Status Verified: 2025-05
• Study First Submitted: 2025-05-29
• Study First Submitted QC: 2025-05-29
• Last Update Submitted: 2025-05-29
• Study First Posted: 2025-06-06
• Last Update Posted: 2025-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 362

Inclusion Criteria

• Age≥14years old and ≤80 years old
• The initial diagnosis is acute gastrointestinal perforation

Exclusion Criteria

• Patients with unconsciousness,or patients with past psychiatric history
• Patients with shock and/or severe organ failure
• Patients who are pregnant
• Patients with severe spinal deformity who are unable to receive epidural anesthesia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
change of the c-reactive protein in plasma	1, 3, and 7 days after surgery
change of the prealbumin in plasma	1, 3, and 7 days after surgery
change of the procalcitonin in plasma	1, 3, and 7 days after surgery

Trial Locations

Locations (1)

the Second Hospital of Hebei Medical University; 🇨🇳 Shijiazhuang, Hebei, China