Effect of selenium therapy on primary autoimmune hypothyroidism: a randomized clinical trial
Phase 2
- Conditions
- Primary autoimmune hypothyroidism.Autoimmune thyroiditis
- Registration Number
- IRCT201211239014N13
- Lead Sponsor
- Vice chancellor for Research the Technology, Hamadan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
(a) age of 18 to 75 years; (b) having primary autoimmune hypothyroidisms; (c) having anti-TPO >200 U/ml
Exclusion criteria: (a) history of Thyroid surgery; (b) history of thyroid cancer; (c) hypothyroidism resulted from hyperthyroidism; (d) history of auto-immune disease and known rheumatologic diseases; (e) pregnancy; (f) renal failure; (g) subclinical hypothyroidism; (h) history of using radioactive iodine, anti thyroid medication, cytotoxic; immunosuppressive, glucocorticoid, amiodaron, lithium, interferon, and chemotherapy
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of anti-TPO titer. Timepoint: ?After three months. Method of measurement: Through electrochemiluminescence using diasorin set and liaison kit.
- Secondary Outcome Measures
Name Time Method TSH. Timepoint: 3 months post intervention. Method of measurement: Laboratory.;T3. Timepoint: 3 months post intervention. Method of measurement: Laboratory.;T4. Timepoint: 3 months post intervention. Method of measurement: Laboratory.;Abdominal pain. Timepoint: 3 months post intervention. Method of measurement: With question.;Hair loss. Timepoint: 3 months post intervention. Method of measurement: With question.;Dizziness. Timepoint: 3 months post intervention. Method of measurement: With question.;Sensation of garlic smell. Timepoint: 3 months post intervention. Method of measurement: With question.;Tremor. Timepoint: 3 months post intervention. Method of measurement: With question.;Sweating. Timepoint: 3 months post intervention. Method of measurement: With question.