Opioid sparing effects of intra-venous paracetamol after Percutaneous Nephrolithotomy: a randomized double blinded controlled trail
- Conditions
- PCNL.Calculus of kidney
- Registration Number
- IRCT201105166504N1
- Lead Sponsor
- Tehran University of Medical Sciences-Vice Chancellor for Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Renal calculi candidate for PCNL; Age between 18 -70 years old; American Society of Anesthesiologists (ASA) risk class I (normal healthy patient)).
Exclusion criteria:
Pregnancy and lactation; Drug and alcohol abuse; Previous history of any allergy to acetaminophen and opioid; Previous history of hepatic (transaminase exciding two times and more of normal limits) or renal failure (serum creatinine exciding 1.5 mg/dl); Bleeding tendency; Consumption of mono-amino-oxidase inhibitors (MAO inhibitors) or their discontinue over past 2 weeks; Other painful physical conditions which might confound pain assessment; Psychiatric or medical conditions that might impair communication or compliance with the study procedures; Use of NSAIDs or other analgesic drug within 12 h preceding study medications; Age below 18 and above 70 years old
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain score. Timepoint: every 4 hours. Method of measurement: VAS.;Paracetamol dose. Timepoint: every 8 hours. Method of measurement: patient records.
- Secondary Outcome Measures
Name Time Method Pethidine dose. Timepoint: After PCNL surgery. Method of measurement: Patients' records.