The Role of Skin Microbiota in Establishing Retinol Tolerance and Achieving Anti-Aging Effects of Retinol

Recruitment & Eligibility

Status: Completed

Sex: Female

Target Recruitment: Not specified

Inclusion Criteria

General Criteria: healthy females, aged 20-40 years old; pass the lactate allergy test; subjects with dull and lifeless complexion; able to cooperate well with the experimenter and maintain regularity of life during the study period; able to read and understand all the contents of the informed consent form and sign it voluntarily; agreeing to refrain from the use of any cosmetic products, medications, and healthcare products during the trial period that would have an effect on the results; and other inclusion criteria as appropriate.<br>Special criteria:<br>(1) Scientific Question 1: Never used a retinol product; demonstrated symptoms of intolerance after initial retinol use.<br>(2) Scientific Question 2: Never used a retinol product; did not show symptoms of intolerance after initial retinol use.

Exclusion Criteria

Patients with any of the following conditions must be excluded from the study: facial skin diseases that may affect the judgement of the test results; highly allergic; pregnant, breastfeeding, or intending to become pregnant during the trial period; severe cardiac, hepatic, renal impairment and severe immunocompromise; mental illness, severe endocrine disease, and oral contraceptive pills; participation in drug clinical trials or other tests within 30 days; oral and topical use of beauty products within 2 weeks that may affect the test results; inability to cooperate with the trial; participation in a drug Clinical or other trials within 30 days, or systemic use of drugs that may affect the results of the test within 1 week; oral and topical use of cosmetic products that may affect the results of the test within 2 weeks; inability to co-operate with the test; in the opinion of the investigator, unsuitable for participation in the study; adverse reactions during the test period, which are judged by a dermatologist to be inappropriate to continue to participate in the test; and other appropriate exclusion criteria.

Study & Design

Study Type: Interventional study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Water content of the stratum corneum on cheeks;Transepidermal water loss on cheeks;Skin surface pH;Skin oil content;Facial porphyrin area;Facial pore size;Percentage of skin red zone area;Skin colour Lab values;Number, length, area and volume of wrinkles at the corners of the eyes;Skin microbiome metagenomics sequencing;Skin metabolite Testing;

Secondary Outcome Measures