Drugs to reduce Heart rate and Blood pressure during Anaesthesia

Not Applicable

Completed

• Conditions: Stress Response (Heart Rate , Blood Pressure)

• Registration Number: CTRI/2018/05/014172
• Lead Sponsor: Sree Gokulam Medical College And Research Foundation

Brief Summary

Hypertension and tachycardia occurring during laryngoscopy and intubation could be deleterious to certain patients. The present study was designed to compare the effectiveness of Esmolol and Lignocaine in attenuating the stress response to laryngoscopy and intubation in 60 normal healthy patients of ASA grade I and II , of either sex , in the age group of 18-60 years for elective noncardiac surgery requiring general anaesthesia. This was done by noting the pressor response variables namely Heart rate, Systolic blood pressure, Diastolic blood pressure and Mean arterial pressure. The trends of these parameters were noted at frequent intervals in the first 8 minutes after induction of anaesthesia. There were no arrythmias. The results were statistically analysed . Compared with the Lignocaine group, the attenuation of stress response variables were better in the Esmolol group. Esmolol was found to be more effective than Lignocaine  in controlling the stress response to larngoscopy and intubation. Esmolol 1 mg/kg was found to be safe and effective  in controlling the pressor response to laryngoscopy and intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-09-26
• Study Completion: 2013-09-26
• Last Update Posted: 2018-10-05

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA I, II Mallampatti Class I or II Age : 18-60 yrs Weight : 40 – 90 kg Elective non-cardiac surgery.

Exclusion Criteria

• Heart rate <70/mt.
• Basal systolic BP<100mm Hg H/o of asthma, cardiac disease & presence of heart block.
• ASA PS > II Anticipated difficult intubation Anxious or apprehensive patients Intubation time more than 15 seconds.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevention of rise in Blood Pressure and Heart Rate due to laryngoscopy and intubation	T0 : Baseline recording on entering the operating room. | T1 :Just before induction | T2 : During laryngoscopy and intubation | T3 :1 min after laryngoscopy | T4 : 3 min after laryngoscopy | T5: 5 min after laryngoscopy

Secondary Outcome Measures

Name	Time	Method
Assessment of safety of Esmolol and Lignocaine administered ( monitoring for arrythmias)	T0 : Baseline recording on entering the operating room.

Trial Locations

Locations (1)

Sree Gokulam Medical College And Research Foundation; 🇮🇳 Thiruvananthapuram, KERALA, India

Sree Gokulam Medical College And Research Foundation

🇮🇳Thiruvananthapuram, KERALA, India

Dr Sonia M Lal

Principal investigator

9846242421

sonnik1@rediffmail.com