Sit-to-stand and Peripheral Muscle Strength in COPD

Not Applicable

Completed

• Conditions: COPD
• Interventions: Other: rehabilitation

• Registration Number: NCT02487875
• Lead Sponsor: Maugeri Foundation

Brief Summary

Background: Individuals with COPD may present reduced peripheral muscle strength, which leads to impaired mobility. Comprehensive pulmonary rehabilitation (PR) should include strength training, in particular to lower limbs. Furthermore, simple tools for the assessment of lower extremity muscles' performance are required. Objectives: To assess the muscle strength of COPD patients by the sit-to-stand test (STST) as compared to the one-repetition maximum (1-RM), considered as the gold standard in non-laboratory situations, and to evaluate the responsiveness of STST to a PR program with specific strength training (SPR), compared to usual PR program (UPR). Methods: 60 moderate-to-severe COPD inpatients were randomly included into either the SPR or into the UPR. 30-sec STST, 1-min STST, 1-RM and 6MWT were assessed before and after PRs.

Detailed Description

Background: Individuals with COPD may present reduced peripheral muscle strength, which leads to impaired mobility. Comprehensive pulmonary rehabilitation (PR) should include strength training, in particular to lower limbs. Furthermore, simple tools for the assessment of lower extremity muscles' performance are required. Objectives: To assess the muscle strength of COPD patients by the sit-to-stand test (STST) as compared to the one-repetition maximum (1-RM), considered as the gold standard in non-laboratory situations, and to evaluate the responsiveness of STST to a PR program with specific strength training (SPR), compared to usual PR program (UPR). Methods: 60 moderate-to-severe COPD inpatients were randomly included into either the SPR or into the UPR. 30-sec STST, 1-min STST, 1-RM and 6MWT were assessed before and after PRs.

Study Timeline

• Study Start: 2014-01
• Primary Completion: 2015-04
• Study Completion: 2015-04
• Status Verified: 2015-06
• Study First Submitted: 2015-06-25
• Study First Submitted QC: 2015-06-29
• Last Update Submitted: 2015-06-29
• Study First Posted: 2015-07-02
• Last Update Posted: 2015-07-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• diagnosis for COPD according to the GOLD criteria.
• no exacerbations over the previous four weeks
• completing PR program
• smoking history ≥10 pack years
• regular treatment with inhaled bronchodilators and inhaled steroids

Exclusion Criteria

• any unstable medical condition
• Contraindications for participation in the PR program included musculoskeletal disorders, malignant diseases, unstable cardiac condition, and lack of adherence to the program

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
COPD patients -study group	rehabilitation	COPD inpatients GOLD2-4, in stable conditions,hospitalized to follow a pulmonary rehabilitation programme. The study group performs in addition to the standard programme, also a peripheric muscle strength training
COPD patients -control group	rehabilitation	COPD inpatients GOLD2-4, in stable conditions,hospitalized to follow a pulmonary rehabilitation programme

Primary Outcome Measures

Name	Time	Method
evaluate the lower limbs' muscle strength by two STSTs (30-sec and 1-min), as compared to the 1-RM in patients with clinically stable COPD, both at baseline and after a PR with specific lower limbs' muscle strength training (SPR).	1 month

Trial Locations

Locations (1)

Fondazione Maugeri di Tradate; 🇮🇹 Tradate, VA, Italy