The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block

Phase 4

Completed

• Conditions: The Duration of Motor Block May Vary Between 12-36 Hrs
• Interventions: Drug: Bupivacaine; Drug: Ropivacaine

• Registration Number: NCT01272921
• Lead Sponsor: Northwestern University

Brief Summary

The duration of motor block for infragluteal parabiceps sciatic nerve block following total knee replacement may vary between 12-36 hrs depending on the amount of local anesthetic given.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11
• Study First Submitted: 2011-01-07
• Study First Submitted QC: 2011-01-07
• Study First Posted: 2011-01-10
• Primary Completion: 2012-08
• Results First Submitted: 2013-09-30
• Results First Submitted QC: 2014-02-04
• Results First Posted: 2014-03-21
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-08
• Last Update Posted: 2017-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 142

Inclusion Criteria

• Adult patients (>18 years of age) who are undergoing elective total knee arthroplasty will be included in the study.

Exclusion Criteria

• Exclusion criteria for the study are patient refusal to be included in the study, contraindications to regional anesthesia, history of allergy to amide local anesthetics, the presence of a progressive neurological deficit, the presence of coagulopathy or infection, or pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Bupivacaine	Bupivacaine	Varying does to determine duration of analgesia following a sciatic nerve block
Ropivacaine	Ropivacaine	Varying does to determine duration of analgesia following a sciatic nerve block

Primary Outcome Measures

Name	Time	Method
Duration of Motor and Sensory Block of the Sciatic With 0.5% Bupivacaine and Ropivacaine After Ultrasound-guided Nerve-stimulator-Assisted Needle Positioning Beneath the CIEL	3 days	Subject reported and investigator measured motor and sensory blockade of the sciatic nerve with less than 10ml of 0.5% bupivacaine and ropivacaine after ultrasound-guided nerve-stimulator-assisted needle positioning beneath the common investing external layer (CIEL).

Secondary Outcome Measures

Name	Time	Method
Cumulative Probabilities for Needle Positioning Above and Below CIEL.	1 Day	The cumulative probability distributions for the minimal current to evoke a motor response with the needle tip positioned external (above) to the common investing extraneural layer (CIEL) and the cumulative probability distribution for the needle tip postioned internal (below) to the CIEL were sought. The difference in the mean minimum threshold current (mA) for the external (above) and internal (below) CIEL positioning were calculated.

Trial Locations

Locations (1)

Northwestern University, Feingberg School of Medicine; 🇺🇸 Chicago, Illinois, United States