A clinical trial to study the mechanism of action of papaya leaf extract in dengue patients
Phase 4
- Conditions
- Health Condition 1: null- non-severe dengue patients.
- Registration Number
- CTRI/2014/10/005120
- Lead Sponsor
- Jawaharlal Institute of Post graduate Medical Education and Research JIPMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
ï??Dengue Fever Subjects 18-60 yrs positive for dengue NS1 antigen or anti IgM/IgG dengue antibodies or virus by Reverse Transcriptase PCR.
Exclusion Criteria
ï??Dengue fever group C and those with bleeding manifestations other than petechiae/purpura
ï?? Pregnant or lactating women.
ï??Known case with hepatic and renal diseases.
ï??Patients with inherited platelet disorders
ï??Patients on medications which interfere with platelet function (NSAIDs) will be excluded from the study.
ï??History of allergic reactions to papaya.
ï??Patients with more than 2 episodes of vomiting in the past 24 hours.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method supplementation of papaya leaf extract to dengue patients increases platelet aggregation,decreases membrane fluidity and p-selectin expressionTimepoint: 1st day, 3rd day and 7th day of start of intervention
- Secondary Outcome Measures
Name Time Method Improvement in platelet count and hematocrit value.Timepoint: 0,3rd and 7th day