Functional neural networks in dementia; a longitudinal MEG study

Conditions: Alzheimer's disease
dementia
10029305

Registration Number: NL-OMON33698

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

For patients:
o Age between 18 and 85
o Minimal MMSE score of 18
o Recently diagnosed with *mild to moderate* Alzheimer*s disease or Frontotemporal dementia
o Written informed consent
For healthy controls:
o Age between 18 and 85
o Written toestemming

Exclusion Criteria

For both patients and healthy controls:
o Other neurodegenerative or cerebrovascular disease
o Psychiatric disease or symptoms
o Insufficient mastery of the Dutch language
o Inability to communicate adequately.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Measures of functional connectivity; the synchronization likelihood and phase<br /><br>lag index (these are quantitative variables derived by a mathematical procedure<br /><br>using the original MEG signal).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Main network variables (described by graph theory applied to functional<br /><br>connectivity measures of MEG recordings) between patients and controls; the<br /><br>cluster coefficient (measure of local network structure) and the path length<br /><br>(measure of global network structure)<br /><br>MMSE score and outcomes of other neurological tests.</p><br>