Correlating invasive and non-invasive measures of coronary flow in patients with angina

Not Applicable

• Conditions: Coronary microvascular dysfunction; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12621001682831
• Lead Sponsor: Abbott Vascular

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-12-09
• Last Update Posted: 13 December 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients referred for coronary angiography for investigation of ischaemic chest pain. Inclusion criteria for group 1 is that they have normal epicardial vessels (<30% diameter stenosis) who will undergo invasive coronary flow reserve (CFR) and index of microvascular resistance (IMR) at the time of coronary angiogram.
Inclusion criteria for group 2 is that they have a moderate-severe lesion on coronary angiogram in either the RCA or LAD, who will undergo fractional flow reserve (FFR), CFR and IMR in both the culprit and non-culprit vessel.

Exclusion Criteria

-Patients with a rise in high-sensitivity troponin I in concert with their ischaemic symptoms
-Pregnant and breastfeeding women, due to the radiation exposure inherent to this study
-Patients with allergies to iodine contrast
-Patients with contraindications to adenosine including: asthma/bronchospasm, greater than first degree heart block or sick sinus syndrome without a pacemaker, symptomatic aortic stenosis or hypertrophic cardiomyopathy, hypotension (SBP < 90 mmHg), unstable angina, cerebral ischaemia or current dipyridamole medication use.
-Patients with previous evidence of myocardial infarction (such as history of STEMI, NSTEMI) or baseline perfusion abnormalities on SPECT to suggest previous myocardial infarction given it may impact the measurements of FFR/CFR/IMR).

Study & Design

• Study Type: Observational
• Study Design: Not specified