Einfluss Der Süßintensität Einer Saccharose-Lösung Auf Die Blutglukoseregulation Und Energieaufnahme in Gesunden Männern
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Blood glucose concentration
研究概览
简要总结
The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose concentration and regulation of hunger & satiety.
详细描述
The study is designed as a randomised cross-over intervention study with four interventions. The study investigates the influence of sweetness modulation by Rebaudioside M (sweetness enhancement) and Lactisol (sweetness inhibition) of a 10% sucrose solution, corresponding to the concentration of a regular soft drink, on blood glucose regulation (blood glucose concentration and regulating hormones) in healthy male volunteers. Furthermore, the study assesses ad libitum energy intake, individual feelings of hunger and satiety, metabolic responses to the interventions, and preference for sweet-tasting foods such as sugar and sweeteners. In addition, the participants' individual thresholds for sweet taste, as well as morphological markers for taste sensitivity and body composition will be recorded as potential influencing factors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •non-smoking
- •normal taste responses towards sweet taste
排除标准
- •regular smokers
- •disturbed glucose and/or lipid metabolism
- •regular intake of medication
- •known allergies against one of the test compounds
- •alcohol or drug addiction
- •intake of antibiotics within the past 2 months
研究组 & 干预措施
Sucrose
10% solution in water
干预措施: Sucrose (Other)
Sucrose + Reb M
10% sucrose + 60 mg/L Rebaudioside M
干预措施: Rebaudioside M (Drug)
Sucrose + Reb M
10% sucrose + 60 mg/L Rebaudioside M
干预措施: Sucrose (Other)
Sucrose + Lactisole
10% sucrose + 30 mg/ L Lactisole
干预措施: Lactisole (Drug)
Sucrose + Lactisole
10% sucrose + 30 mg/ L Lactisole
干预措施: Sucrose (Other)
Sucrose + Reb M + Lactisole
10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole
干预措施: Lactisole (Drug)
Sucrose + Reb M + Lactisole
10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole
干预措施: Rebaudioside M (Drug)
Sucrose + Reb M + Lactisole
10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole
干预措施: Sucrose (Other)
结局指标
主要结局
Blood glucose concentration
时间窗: over a time span of 120 minutes after drinking the test solution
Glucose concentration \[mg/dL\] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
GLP-1 concentration
时间窗: over a time span of 120 minutes after drinking the test solution
Glucagon-like peptide 1 concentration in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
GIP-concentration
时间窗: over a time span of 120 minutes after drinking the test solution
Gastric inhibitory polypeptide concentration in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
Insulin concentration
时间窗: over a time span of 120 minutes after drinking the test solution
Insulin concentration \[mmol/L\] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
次要结局
- Metabolic changes(over a time span of 120 minutes after drinking the test solution)
- Food intake(120 minutes after drinking of the test solution)
研究者
Barbara Lieder
Deptuy Head Department of Physiological Chemistry
University of Vienna