Resolvin D1 Levels in Patients With Periodontitis

Not Applicable

Completed

• Conditions: Periodontitis

• Registration Number: NCT04496570
• Lead Sponsor: T.C. ORDU ÜNİVERSİTESİ

Brief Summary

The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.

A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-07-31
• Primary Completion: 2020-02-29
• Study Completion: 2020-02-29
• Study First Submitted: 2020-07-29
• Study First Submitted QC: 2020-07-29
• Status Verified: 2020-08
• Study First Posted: 2020-08-03
• Last Update Submitted: 2020-08-17
• Last Update Posted: 2020-08-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Stage 3, Grade B and generalized periodontitis patients

Exclusion Criteria

• excessive forces;
• presence of systemic diseases
• administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
• having received non-surgical periodontal treatment within the past 6 months
• allergy or sensitivity to any drug,
• pregnancy, lactation
• current and former use of tobacco.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Biochemical parameter (resolvin D1)	Baseline and 1 month after NSPT	The changes in levels of resolvin D1 after periodontal treatment determined by ELISA.

Secondary Outcome Measures

Name	Time	Method
Clinical attachment level (CAL)	Baseline and 1 month after NSPT	The changes in CAL after periodontal treatment were evaluated
Gingival index (GI)	Baseline and 1 month after NSPT	The changes in GI after periodontal treatment were evaluated
Plaque index (PI)	Baseline and 1 month after NSPT	The changes in PI after periodontal treatment were evaluated
Probing pocket depth	Baseline and 1 month after NSPT	The changes in probing pocket depth after periodontal treatment were evaluated

Trial Locations

Locations (1)

Ordu University; 🇹🇷 Ordu, Turkey