Integrated Diagnosis and Treatment of CKD on Outcomes

Recruiting

• Conditions: Anemia; Chronic Kidney Disease-Mineral and Bone Disorder; Malnutrition; Hyperlipidemias; Chronic Kidney Diseases; Hypertension; Hyperglycemia
• Interventions: Other: Integrated diagnosis and treatment for CKD

• Registration Number: NCT05242055
• Lead Sponsor: Capital Medical University

Brief Summary

Objective: To establish a study cohort and follow up of patients with CKD in our hospital, and evaluate the status of integrated CKD diagnosis and treatment according to guidelines in the real world, as well as the clinical prognosis of patients with different stratification.

Methods: By establishing a cohort of 1000 patients with CKD and conducting long-term follow-up, integrated diagnosis and treatment for CKD was performed, namely: Regular monitoring, control of blood pressure, blood glucose, blood lipid, correction of anemia, minerals - bone metabolic abnormalities, malnutrition, acid and alkali, and electrolyte disorder, diet and exercise, such as the guidance of integrated management, non intrusive, observational studies, prospective cohort were analyzed retrospectively, describe the implementation of the integration of diagnosis and treatment, chronic kidney disease (CKD) Stratified analysis and risk factor analysis were performed for cardiovascular disease and other main endpoint events, so as to objectively reflect the status of integrated treatment of CKD and provide data support for continuous quality improvement of CKD diagnosis and treatment and improvement of clinical prognosis of patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-01-29
• Study Start: 2022-02-01
• Study First Submitted QC: 2022-02-12
• Study First Posted: 2022-02-16
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-02
• Last Update Posted: 2022-05-06
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• ≥18 years old;
• Voluntarily signed informed consent;
• Patients who are estimated to develop CKD.

Exclusion Criteria

• Age < 18 or ≥100 years;
• Unable to comply with the procedures stipulated in this study;
• Estimated follow-up time ≤6 months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Integrated group	Integrated diagnosis and treatment for CKD	Patients in the integrated group should be the patients getting integrated diagnosis and treatment during following up period. Integrated diagnosis and treatment includes control of hypertension, hyperglycemia, hyperlipidemia, anemia, CKD-MBD, and malnutrition by regular follow-up according to the guidelines of Kidney Disease- Improving Global Outcomes and of Chinese Medical Association in 2021.
Unintegrated group	Integrated diagnosis and treatment for CKD	Patients in the unintegrated group are those who do not follow the contents of guidelines in some items of the integrated diagnosis and treatment during follow-up.

Primary Outcome Measures

Name	Time	Method
Rate of cardiovascular cerebrovascular adverse events	Six months or more	Acute myocardial infarction, heart failure, shock, cardiac arrest, stroke, and lower limb arterial occlusion occurred during follow-up

Secondary Outcome Measures

Name	Time	Method
Rate of all-cause mortality	Six months or more	Deaths from all causes during follow-up

Trial Locations

Locations (1)

Nephrology Department of Beijing Jishuitan Hospital; 🇨🇳 Beijing, Beijing, China